(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine]
(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine], CAS 192138-05-9, is a sophisticated atropisomeric phosphine ligand. With a molecular weight of 1031.46 g/mol and empirical formula C70H96O2P2, this compound is a crucial tool in asymmetric synthesis. It is widely employed as a chiral catalyst or ligand in various stereoselective organic transformations, facilitating the efficient production of enantiomerically pure compounds.
- IUPAC
- (R)-2,2′-Bis[bis(3,5-di-tert-butyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl,(R)-3,5-t-Bu-MeOBIPHEP,SL-A121-1
- Synonyms
- (R)-3,5-t-Bu-MeOBIPHEPSL-A121-1(R)-2,2′-Bis[bis(3,5-di-tert-butyl)phosphino]-6,6′-dimethoxy-1,1′-biphenyl
![(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine] (C70H96O2P2) — chemical structure, CAS 192138-05-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F192138-05-9.png&w=3840&q=75)
Asymmetric Catalysis
This ligand is integral to a range of asymmetric catalytic reactions, enabling the stereoselective synthesis of chiral molecules. Its unique atropisomeric structure allows for high enantiocontrol in transformations such as hydrogenation, allylic alkylation, and conjugate additions.
Chiral Ligand Development
As a member of the MeOBIPHEP ligand family, it serves as a benchmark for developing new chiral ligands. Researchers utilise its established performance to design novel catalytic systems with enhanced activity and selectivity for specific synthetic challenges.
Pharmaceutical Intermediate Synthesis
The ability to control stereochemistry is paramount in pharmaceutical development. This ligand plays a vital role in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and their precursors, ensuring the efficacy and safety of drug candidates.
| Molecular weight | 1031.46 |
|---|---|
| Empirical formula | C70H96O2P2 |
| Assay | ≥97% |
| Optical purity | ee: ≥99% |
| Application | Atropisomeric MeOBIPHEP ligands |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine] used for?
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(R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine] is primarily used as a chiral ligand in asymmetric synthesis and catalysis. It facilitates the stereoselective production of chiral molecules, which is crucial in pharmaceutical and fine chemical manufacturing.
What is the CAS number and formula for this compound?
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The CAS number is 192138-05-9, and the empirical formula is C70H96O2P2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of ≥97% and an optical purity of ee: ≥99%. We do not represent this product as USP, BP, or EP grade.
How should (R)-(6,6′-Dimethoxybiphenyl-2,2′-diyl)bis[bis(3,5-di-tert-butylphenyl)phosphine] be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified under WGK Germany 3, indicating a hazard to water.
Is this compound suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including this compound.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales department through the website or by phone. Our team will be happy to assist you with your specific requirements.
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