Poloxamer 188 solution

CAS 9003-11-6Biochemicals & Reagents

Poloxamer 188 solution (CAS 9003-11-6) is a non-ionic, amphiphilic block copolymer with an average molecular weight of 8350. As a PREMIUM BioReagent grade material, it functions effectively as a surfactant and is suitable for cell culture applications. This solution is sterile-filtered and supplied at a 10% concentration. Its properties make it valuable in various laboratory and research settings, particularly where biocompatibility and surface activity are required.

IUPAC: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol),Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol)
Synonyms: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)Poly(propylene glycol)-block-poly(ethylene glycol)-block-poly(propylene glycol)EO-PO-EO Copolymer

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Poloxamer 188 solution — chemical structure, CAS 9003-11-6; Life Science, fine chemical supplied by Tech Serve Solutions

Amphiphilic Block CopolymersBiochemicals and ReagentsBiological DetergentsBlock CopolymersCell CultureDetergentsDetergents N to ZDetergents by ApplicationsDiagnostic ApplicationsDrug Delivery-Liposomes

01 /Applications

Surfactant and Emulsifier

Poloxamer 188 acts as a non-ionic surfactant, reducing surface tension in aqueous solutions. Its amphiphilic nature allows it to stabilise emulsions and suspensions, proving useful in various formulation and laboratory procedures.

Cell Culture Applications

This sterile-filtered solution is suitable for cell culture, where its biocompatibility and low toxicity are advantageous. It can be used to improve cell viability and protect cells during cryopreservation or other stress conditions.

Biochemical Research

As a premium biochemical reagent, Poloxamer 188 finds use in solubilising membrane proteins and in drug delivery systems. Its defined structure and properties aid in reproducible experimental outcomes.

Diagnostic Reagent Component

Its properties as a non-ionic surfactant make it suitable for use in diagnostic applications, potentially in improving the stability and performance of assay reagents.

02 /Properties

Density	1.020 g/mL at 20 °C
Refractive index	n20/D 1.455
Solubility	H2O: soluble0.25 g/10 mL, clear, colorless
pH	5.0-7.5 (100 g/L in H2O)6.0-7.5 (25 g/L in H2O)
Concentration	10%
Vapour pressure	<0.3 mmHg (20 °C)
Vapour density	>1 (vs air)
Melting point	56-61 °C
Viscosity	1380 mPa.s(20 °C)
Storage temperature	2-8°C
Impurities tested	≤0.5% water
Application	A nonionic copolymer surfactant
Suitability	suitable for cell culture

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Ignition residue	≤0.30%

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

9003-11-6

MDL number

MFCD00082049

PubChem substance

24898666

05 /Additional specifications

Quality Level	PREMIUM
Description	non-ionic
Product Line	BioReagent
Mol Wt	average mol wt 8350
Transition Temp	cloud point ≥100
Uv Absorption	λ: 260 nm Amax: ≤0.3λ: 280 nm Amax: ≤0..2
Cmc	950-1000 ppm (~25°C)
Sterility	sterile-filtered
Hlb	29
Hydroxyl Value	6‑9 mg KOH/g
Feed Ratio	20:70:20 (EO:PO:EO)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Poloxamer 188 solution used for?

Poloxamer 188 solution (CAS 9003-11-6) is used as a non-ionic surfactant, in cell culture, for solubilising membrane proteins, and in drug delivery systems, with applications in biochemical research and diagnostics.

What are the CAS number and formula for Poloxamer 188 solution?

The CAS number for Poloxamer 188 solution is 9003-11-6. Its formula is not explicitly provided, but it is a block copolymer of ethylene oxide and propylene oxide.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Poloxamer 188 solution at a PREMIUM BioReagent grade, supplied as a 10% sterile-filtered solution. We do not represent this product as USP, BP, or EP grade.

How should Poloxamer 188 solution be handled and stored?

Handle with appropriate personal protective equipment, including eyeshields and gloves. Store the solution at 2-8°C. Refer to the safety data sheet for comprehensive handling information.