Picrotoxinin
Picrotoxinin (CAS: 17617-45-7, C15H16O6, MW: 292.28) is a highly toxic, bitter crystalline substance. It is a potent non-competitive antagonist of the GABA-A receptor, commonly utilised in neuroscience research to study neuronal excitability and the function of GABAergic neurotransmission. Its specific action on ligand-gated ion channels makes it a valuable tool for investigating synaptic mechanisms and related neurological processes.
Neuroscience Research
Picrotoxinin is extensively used as a pharmacological tool to block GABA-A receptors. This blockade helps researchers investigate the role of inhibitory neurotransmission in various physiological and pathological conditions of the nervous system.
Ion Channel Modulation Studies
As a ligand-gated ion channel modulator, Picrotoxinin is employed to study the function and regulation of ion channels, particularly in the context of neuronal signalling and excitability.
Cellular Signalling Investigations
Its ability to interfere with neurotransmitter systems makes Picrotoxinin useful for exploring complex cellular signalling pathways within neurons and other excitable cells.
| Molecular weight | 292.28 |
|---|---|
| Empirical formula | C15H16O6 |
Hazard statements
- H300Fatal if swallowed
Precautionary statements
- P264Wash thoroughly after handling
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 28 |
| Safety statements (S) | 28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Picrotoxinin used for?
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Picrotoxinin is primarily used in neuroscience research as a GABA-A receptor antagonist to study neuronal excitability, inhibitory neurotransmission, and ion channel function.
What are the CAS number and formula for Picrotoxinin?
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The CAS number for Picrotoxinin is 17617-45-7 and its molecular formula is C15H16O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Picrotoxinin primarily for research and laboratory use. The specific grade and purity are detailed on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should Picrotoxinin be handled safely?
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Picrotoxinin is classified as toxic and extremely hazardous. Handle with extreme caution using appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (e.g., N100 or P3 filters). Ensure adequate ventilation. Consult the Safety Data Sheet (SDS) for full details.
Is Picrotoxinin a controlled substance?
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Based on the provided data, Picrotoxinin is not explicitly listed as a controlled substance. However, its high toxicity necessitates careful handling and adherence to all relevant regulations.
How is Picrotoxinin packed and shipped?
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Picrotoxinin is packed and shipped in accordance with international regulations for hazardous materials, indicated by UN 2811, Class 6.1, Packing Group II. TSS is an experienced global exporter.
How can I request a sample or quote for Picrotoxinin?
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To request a sample or a quote for Picrotoxinin, please contact our sales team through the website or by email, providing your specific requirements and shipping details.
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