O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol
O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol (CAS 92451-00-8) is a monofunctional polyethylene glycol derivative featuring an N-hydroxysuccinimide (NHS) ester. This activated ester allows for covalent conjugation to primary amines under mild conditions, making it valuable in bioconjugation, surface modification, and the synthesis of functionalised polymers. Its polyethylene glycol backbone imparts water solubility and can reduce non-specific binding in biological applications.
- IUPAC
- O-Methyl-O′-[(N-succinimidyl)succinyl-aminoethyl]polyethylene glycol,O-Methyl-O′-[2-(succinylamino)-ethyl]polyethylene glycol N-succinimidyl ester,Ome-PEG-NHS
- Synonyms
- O-Methyl-O′-[2-(succinylamino)-ethyl]polyethylene glycol N-succinimidyl esterOme-PEG-NHS
![O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol — chemical structure, CAS 92451-00-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F92451-00-8.png&w=3840&q=75)
Bioconjugation
The NHS ester readily reacts with primary amines on proteins, peptides, or other biomolecules to form stable amide bonds. This enables the modification of biological entities for research or therapeutic purposes.
Surface Modification
This PEG derivative can be used to functionalise surfaces, such as nanoparticles or sensor chips, by attaching it via its NHS ester to amine-containing substrates. This can alter surface properties like hydrophilicity and biocompatibility.
Polymer Synthesis
It serves as a building block in the synthesis of specialised polymers, allowing for the incorporation of PEG chains with a reactive end group for further functionalisation or cross-linking.
Materials Science Research
Utilised in the development of novel materials where precise control over surface chemistry and hydrophilicity is required, particularly in areas related to biomaterials and drug delivery systems.
| Storage temperature | −20°C |
|---|
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol used for?
+
This compound is primarily used in bioconjugation for attaching to molecules with primary amines, modifying surfaces, and synthesising functionalised polymers due to its NHS ester reactivity and PEG backbone.
What are the CAS number and formula for this product?
+
The CAS number is 92451-00-8. The formula is not provided in the product data.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this product as a research-grade chemical. We do not represent it as USP, BP, EP, or any other pharmacopoeial standard unless explicitly stated in the product specifications.
How should O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol be handled?
+
Handle with appropriate personal protective equipment, including eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter. Store at -20°C.
Is this product suitable for direct use in food or pharmaceuticals?
+
This product is intended for chemical synthesis and research applications. Its suitability for direct use in food or pharmaceuticals depends on specific regulatory requirements and purity standards not detailed in the supplied data.
How is this chemical packed, shipped, and exported?
+
Tech Serve Solutions packs, ships, and exports fine chemicals, pharmaceutical intermediates, and laboratory reagents globally, adhering to relevant shipping regulations. Specific packaging details are determined at the time of order.
How can I request a sample or quote for this product?
+
To request a sample or a quote for O-[(N-Succinimidyl)succinyl-aminoethyl]-O′-methylpolyethylene glycol, please contact our sales department via the website or direct inquiry channels.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis