O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium hexafluorophosphate
O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium hexafluorophosphate (CAS: 333717-40-1) is a uronium-based reagent with a molecular weight of 386.23 g/mol. It is primarily utilised as a coupling reagent in peptide synthesis and for the derivatization of amino acids. This compound offers efficient activation for amide bond formation in chemical synthesis and peptide chemistry applications.
- IUPAC
- 6-Cyano-N,N,2-trimethyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-aminium hexafluorophosphate,HOTU
- Synonyms
- N′-tetramethyluronium hexafluorophosphate333717-40-1C10H17F6N4O3PHOTU
![O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium hexafluorophosphate (N′) — chemical structure, CAS 333717-40-1; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F333717-40-1.png&w=3840&q=75)
Peptide Synthesis Reagent
This compound serves as an effective reagent for peptide coupling, facilitating the formation of amide bonds between amino acids during the synthesis of peptides. Its structure is designed for efficient activation of carboxyl groups.
Chemical Synthesis
Utilised in broader chemical synthesis, it can be employed for derivatization reactions, particularly in the construction of complex organic molecules. Its reactivity makes it suitable for various coupling processes.
Reagent for Amide Bond Formation
The compound is valuable for forming amide bonds, a fundamental reaction in organic chemistry. It is applied in situations requiring efficient coupling, such as in the synthesis of peptide chains or other amide-containing structures.
| Molecular weight | 386.23 |
|---|---|
| Empirical formula | C10H17F6N4O3P |
| Assay | ≥97.0% (HPCE) |
| Storage temperature | 2-8°C |
| Application | Reagent for peptide coupling1,2,3Derivatization for use in peptide synthesis4 |
| Melting point | 128-131 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium hexafluorophosphate used for?
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This compound is primarily used as a reagent for peptide coupling and in general chemical synthesis for derivatization reactions, efficiently facilitating amide bond formation.
What is the CAS number and molecular formula for this compound?
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The CAS number is 333717-40-1, and the molecular formula is C10H17F6N4O3P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥97.0% (HPCE). We do not represent this product as USP, BP, or EP grade.
How should this chemical be handled and stored?
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Handle with appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves. Store at 2-8°C. This compound is a potential irritant to the skin, eyes, and respiratory tract.
Is this chemical suitable for export and international shipment?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents.
How can I request a quote or sample?
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Please contact our sales team via the website or by phone to request a quote or a sample of O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium hexafluorophosphate.
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