Nysted Reagent
Nysted Reagent (CAS 41114-59-4), with the chemical formula C6H12Br2OZn3 and a molecular weight of 456.14 g/mol, is a versatile organozinc reagent. It is supplied as a 20 wt. % suspension in THF. Its primary utility lies in the effective methylenation of ketones and α-ketols, facilitating crucial carbon-carbon bond formation in organic synthesis.
- IUPAC
- cyclo-Dibromodi-μ-methylene[μ-(tetrahydrofuran)]trizinc
Methylenation of Ketones
Nysted Reagent is specifically employed for the conversion of ketones into their corresponding methylene derivatives. This transformation is a key step in various synthetic pathways, allowing for the introduction of a C1 unit.
α-Ketol Methylenation
This reagent proves valuable for the methylenation of α-ketols, enabling the synthesis of vicinal diols or epoxides depending on subsequent reaction conditions. It is a specialized application in stereoselective synthesis.
C-C Bond Formation
As a reagent involved in olefination reactions, Nysted Reagent participates in the formation of new carbon-carbon double bonds. This is fundamental in constructing complex organic molecules from simpler precursors.
Synthetic Reagent
Nysted Reagent serves as a valuable tool in general chemical synthesis, offering a reliable method for specific functional group transformations. Its use contributes to the efficient preparation of target compounds in research and development.
| Molecular weight | 456.14 |
|---|---|
| Empirical formula | C6H12Br2OZn3 |
| Density | 1.186 g/mL at 25 °C(lit.) |
| Concentration | 20 wt. % suspension in THF |
| Application | Useful reagent for the methylenation of ketones and α-ketols. |
Hazard statements
- H225Highly flammable liquid and vapour
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -26 °C / -14.8 °F |
|---|---|
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-19-36/37 |
| Safety statements (S) | 16-26 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nysted Reagent used for?
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Nysted Reagent is primarily used for the methylenation of ketones and α-ketols, facilitating carbon-carbon bond formation in organic synthesis.
What are the CAS number and chemical formula for Nysted Reagent?
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The CAS number for Nysted Reagent is 41114-59-4, and its chemical formula is C6H12Br2OZn3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nysted Reagent as a 20 wt. % suspension in THF. We do not represent this product as USP, BP, or EP grade.
How should Nysted Reagent be handled safely?
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Nysted Reagent is a flammable liquid and vapour (H225), causes serious eye damage (H318), and may cause respiratory irritation (H335). It may form explosive peroxides. Handle with appropriate precautions, including avoiding heat, sparks, open flames, and hot surfaces, and use in a well-ventilated area. Refer to the Safety Data Sheet for full handling instructions.
Is Nysted Reagent a controlled substance?
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The provided data does not indicate that Nysted Reagent is a controlled substance.
How is Nysted Reagent packed and shipped?
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Nysted Reagent is shipped as UN 3399, Hazard Class 4.3, Packing Group II. TSS exports globally, adhering to all relevant shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample of Nysted Reagent, please contact our sales team through the TSS website or by phone.
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