NVOC2-Q-rhodamine-5-PEG3-azide
NVOC2-Q-rhodamine-5-PEG3-azide (CAS: 1352809-21-2; C55H56N8O19) is a photoactivatable, caged rhodamine derivative. It features a PEG3 spacer and an azide group for conjugation via click chemistry. Upon UV irradiation, the NVOC cage is cleaved, releasing the fluorescent Q-rhodamine dye. This compound is primarily utilized in chemical biology and conjugation chemistry for creating fluorescent probes and sensors that can be activated spatially and temporally.
- IUPAC
- ortho-Nitroveratryloxycarbonyl-Q-rhodamine-5-PEG3-azide
Fluorescent Probe Development
NVOC2-Q-rhodamine-5-PEG3-azide serves as a precursor for photoactivatable fluorescent probes. Its caged nature allows for controlled fluorescence release, enabling precise imaging and tracking in biological systems.
Bioconjugation Chemistry
The terminal azide group facilitates conjugation to alkyne- or cycloalkyne-modified biomolecules and surfaces via highly efficient click chemistry, enabling the creation of labelled proteins, antibodies, or other biological targets.
Spatial and Temporal Control in Assays
The photo-caging strategy permits the introduction of fluorescence only upon specific light activation, ideal for studying dynamic biological processes or developing spatially resolved assays.
| Molecular weight | 1133.08 |
|---|---|
| Empirical formula | C55H56N8O19 |
| Assay | 95% |
| Storage temperature | −20°C |
| Application | Photoactivatable rhodamine derivative functionalized with a PEG azide. The azide functionality can be used to conjugate this caged rhodamine to alkyne or cycloalkyne containing compounds or biomolecules using the azide-alkyne cycloaddition click chemistry reaction. The ortho-Nitroveratryloxycarbonyl (NVOC) cages can be removed upon irradiation with UV light, restoring the fluorescence of the base dye. NVOC has an absorption max at ~350 nm and has been shown to be cleaved at 350 nm, 405 nm and 420 nm.Q-Rhodamine λ(ex) = 537 nm, λ(em) = 556 nm. |
| Melting point | 178-282 °C (decomposition) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is NVOC2-Q-rhodamine-5-PEG3-azide used for?
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This compound is used in chemical biology for developing photoactivatable fluorescent probes and in conjugation chemistry for labelling biomolecules via click chemistry, allowing for controlled fluorescence release upon UV irradiation.
What is the CAS number and molecular formula for NVOC2-Q-rhodamine-5-PEG3-azide?
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The CAS number is 1352809-21-2 and the molecular formula is C55H56N8O19.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 95%. This is a research-grade chemical and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations for handling NVOC2-Q-rhodamine-5-PEG3-azide?
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The product has a GHS classification with a Water Hazard Class (WGK) of 3 in Germany, indicating it is hazardous to aquatic life. Handle with appropriate personal protective equipment in a well-ventilated area.
How is NVOC2-Q-rhodamine-5-PEG3-azide shipped and exported?
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Tech Serve Solutions, a specialist global supplier and exporter since 1998, can provide details on shipping and export options for this product.
How can I request a quote or sample for NVOC2-Q-rhodamine-5-PEG3-azide?
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Please contact our sales team directly through our website to request a quotation or inquire about sample availability for NVOC2-Q-rhodamine-5-PEG3-azide.
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