N-Hydroxysulfosuccinimide sodium salt
N-Hydroxysulfosuccinimide sodium salt (CAS: 106627-54-7) is a water-soluble derivative of N-hydroxysuccinimide, widely utilised in bioconjugation and chemical synthesis. Its primary function is to activate carboxylic acids for efficient coupling with amines. This reagent is invaluable in peptide synthesis, protein modification, and the preparation of various biomolecular conjugates, offering a reliable method for creating stable amide bonds under mild conditions. Tech Serve Solutions supplies this compound for research and development purposes.
- IUPAC
- Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt,Sulfo-NHS
- Synonyms
- Sulfo-NHSHydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt
Peptide Synthesis
N-Hydroxysulfosuccinimide sodium salt is used to prepare activated esters of amino acids, facilitating peptide bond formation. This is crucial for the efficient synthesis of peptides and peptidomimetics in research and pharmaceutical development.
Bioconjugation
The compound enables the covalent labeling of biomolecules, such as proteins and antibodies, with various functional groups or reporter molecules. Its water solubility makes it ideal for reactions in aqueous environments.
Surface Modification
It can be employed to functionalise surfaces with amine-reactive groups, allowing for the immobilisation of biomolecules or the creation of specific surface properties. This is valuable in diagnostics and biosensor development.
Cross-linking
N-Hydroxysulfosuccinimide sodium salt can be used in the synthesis of cross-linking reagents to study protein-protein interactions or stabilise macromolecular structures.
| Molecular weight | 217.13 |
|---|---|
| Empirical formula | C4H4NNaO6S |
| Assay | ≥98% (HPLC) |
| Impurities tested | ≤4% water |
| Composition | carbon, 21.57-22.68 (anhydrous)nitrogen, 6.28-6.61 (anhydrous) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Hydroxysulfosuccinimide sodium salt used for?
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N-Hydroxysulfosuccinimide sodium salt is primarily used as a water-soluble activating agent for carboxylic acids, facilitating their conjugation with amines. It is essential in peptide synthesis, bioconjugation, protein modification, and surface functionalisation.
What are the CAS number and formula for N-Hydroxysuccinimide sodium salt?
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The CAS number is 106627-54-7. The empirical formula (Hill notation) is C4H4NNaO6S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Hydroxysuccinimide sodium salt with an assay of ≥98% (HPLC). This product is intended for research and development purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling precautions for this chemical?
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Handling N-Hydroxysuccinimide sodium salt requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. Consult the Safety Data Sheet (SDS) for full details.
How is N-Hydroxysulfosuccinimide sodium salt shipped?
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Tech Serve Solutions exports chemicals globally, adhering to all relevant shipping and customs regulations. Specific packaging details are confirmed upon order placement.
How can I request a quote or sample?
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To request a quote or sample of N-Hydroxysulfosuccinimide sodium salt, please use the contact form on our website or contact our sales team directly with your requirements.
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