NVOC2-5-carboxy-Q-rhodamine
NVOC2-5-carboxy-Q-rhodamine (CAS: 1352809-04-1) is a photoactivatable rhodamine derivative with the empirical formula C47H40N4O17 and a molecular weight of 932.84 g/mol. This compound features a carboxylic acid group for conjugation and an ortho-Nitroveratryloxycarbonyl (NVOC) cage, which can be removed with UV light to restore fluorescence. It is primarily used in chemical biology and synthesis as a fluorescent probe.
- IUPAC
- 1′,11′-Bis(((4,5-dimethoxy-2-nitrobenzyl)oxy)carbonyl)-3-oxo-1′,2′,3′,4′,8′,9′,10′,11′-octahydro-3H-spiro[isobenzofuran-1,6′-pyrano[3,2-g:5,6-g′]diquinoline]-5-carboxylic acid,ortho-Nitroveratryloxycarbonyl-5-carboxy-Q-rhodamine
Photoactivatable Fluorescent Probes
NVOC2-5-carboxy-Q-rhodamine serves as a photoactivatable fluorescent probe. The NVOC cage masks the fluorescence of the Q-rhodamine core, allowing for controlled light-induced activation and fluorescence recovery, ideal for spatiotemporal studies.
Bioconjugation and Labeling
The carboxylic acid functionality enables conjugation to amine-containing biomolecules or compounds via amide coupling. This allows for targeted delivery and photo-controlled release of fluorescent signals in biological systems.
Chemical Synthesis Applications
This rhodamine derivative is valuable in chemical synthesis for developing advanced fluorescent tools. Its photo-caging mechanism and conjugation capabilities make it suitable for creating complex molecular architectures and responsive systems.
| Molecular weight | 932.84 |
|---|---|
| Empirical formula | C47H40N4O17 |
| Assay | 97% (HPLC) |
| Storage temperature | −20°C |
| Application | Photoactivatable rhodamine derivative functionalized with a carboxylic acid. The acid functionality can be used to conjugate this caged rhodamine to an amine containing compound or biomolecule through various amide coupling procedures. The ortho-Nitroveratryloxycarbonyl (NVOC) cages can be removed upon irradiation with UV light restoring the fluorescence of the base dye. NVOC has an absorption max at ~350 nm and has been shown to be cleaved at 350 nm, 405 nm and 420 nm.Q-Rhodamine: λex = 537 nm, λem = 556 nm. |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is NVOC2-5-carboxy-Q-rhodamine used for?
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NVOC2-5-carboxy-Q-rhodamine is used as a photoactivatable fluorescent probe in chemical biology and synthesis. Its fluorescence can be uncaged using UV light, and it can be conjugated to biomolecules via its carboxylic acid group.
What are the CAS number and empirical formula for NVOC2-5-carboxy-Q-rhodamine?
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The CAS number is 1352809-04-1, and the empirical formula is C47H40N4O17.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies NVOC2-5-carboxy-Q-rhodamine with a purity of 97% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for this chemical?
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This compound is classified under WGK Germany 3, indicating a high hazard to water. Handle with appropriate personal protective equipment in a well-ventilated area, avoiding contact with skin, eyes, and clothing, and preventing release into the environment.
How is NVOC2-5-carboxy-Q-rhodamine packed, shipped, and exported?
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NVOC2-5-carboxy-Q-rhodamine is typically stored at -20°C. Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping and customs regulations for hazardous materials.
How can I request a sample or quote for NVOC2-5-carboxy-Q-rhodamine?
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To request a sample or a quote, please contact our sales team through the website or via email, providing your contact details and the product's CAS number (1352809-04-1).
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