NVOC2-5-carboxy-Q-rhodamine-NHS ester
NVOC2-5-carboxy-Q-rhodamine-NHS ester (CAS: 1352809-17-6) is a photoactivatable rhodamine derivative with the molecular formula C51H43N5O19. This compound features an ortho-Nitroveratryloxycarbonyl (NVOC) cage, which can be removed by UV irradiation to restore fluorescence. Its succinimidyl ester (NHS) functionality enables conjugation to amine-containing molecules, making it valuable in chemical biology and fluorescent probe applications.
- IUPAC
- 1′,11′-bis{[(4,5-dimethoxy-2-nitrobenzyl)oxy]carbonyl}-3-oxo-1′,2′,3′,4′,8′,9′,10′,11′-octahydro-spiro[isobenzofuran-1(3H),6′-pyrano[3,2-g:5,6-g′]diquinoline]-5-carboxylic acid, 5-succinimidyl ester,ortho-nitroveratryloxycarbonyl-Q-rhodamine-5-succinimidyl ester
Fluorescent Labelling
The succinimidyl ester (NHS) group allows for covalent conjugation to amine-containing biomolecules and compounds. This facilitates the precise labelling of targets for visualisation and detection in biological systems.
Photoactivatable Probes
The NVOC cage can be photolytically cleaved using UV light (350-420 nm), releasing the fluorescent Q-rhodamine dye. This property is useful for controlled fluorescence activation in microscopy and chemical biology experiments.
Chemical Biology Research
As a caged fluorescent probe, this compound is employed in studies requiring spatially or temporally controlled fluorescence. It aids in tracking molecular processes and cellular events with high specificity.
Synthesis of Functionalised Dyes
The NHS ester functionality serves as a reactive handle for synthesising more complex rhodamine-based molecules and probes for advanced research applications.
| Molecular weight | 1029.91 |
|---|---|
| Empirical formula | C51H43N5O19 |
| Assay | 95% (HPLC) |
| Storage temperature | −20°C |
| Application | Photoactivatable rhodamine derivative functionalized with a succinimidyl ester (NHS). The NHS functionality can be used to conjugate this caged rhodamine to amine containing compounds or biomolecules. The ortho-Nitroveratryloxycarbonyl (NVOC) cages can be removed upon irradiation with UV light, restoring the fluorescence of the base dye. NVOC has an absorption max at ~350 nm and has been shown to be cleaved at 350 nm, 405 nm and 420 nm.Q-Rhodamine λ(ex) = 537 nm, λ(em) = 556 nm |
| Melting point | 250-255 °C (decomposition) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is NVOC2-5-carboxy-Q-rhodamine-NHS ester used for?
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NVOC2-5-carboxy-Q-rhodamine-NHS ester is used as a photoactivatable fluorescent probe for labelling amine-containing molecules and biomolecules. Its fluorescence can be uncaged with UV light, making it suitable for controlled activation in chemical biology and microscopy.
What is the CAS number and molecular formula for NVOC2-5-carboxy-Q-rhodamine-NHS ester?
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The CAS number is 1352809-17-6 and the empirical formula is C51H43N5O19.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies NVOC2-5-carboxy-Q-rhodamine-NHS ester with an assay of 95% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should NVOC2-5-carboxy-Q-rhodamine-NHS ester be handled and stored?
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This compound should be stored at -20°C. Handle with appropriate personal protective equipment in a well-ventilated area. Consult the Safety Data Sheet for detailed hazard information and handling precautions.
Is NVOC2-5-carboxy-Q-rhodamine-NHS ester a controlled substance?
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The provided data does not indicate that NVOC2-5-carboxy-Q-rhodamine-NHS ester is a controlled substance.
How is NVOC2-5-carboxy-Q-rhodamine-NHS ester packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals according to international regulations to ensure safe and compliant delivery worldwide.
How can I request a sample or quote for NVOC2-5-carboxy-Q-rhodamine-NHS ester?
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Please contact our sales team via the website or direct email to request a sample or a quotation for NVOC2-5-carboxy-Q-rhodamine-NHS ester.
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