Necrostatin-1
Necrostatin-1 (CAS: 4311-88-0; C13H13N3OS) is a research chemical with a molecular weight of 259.33 g/mol. This compound is primarily recognised as an inhibitor of programmed necrosis (necroptosis). It plays a crucial role in cellular biology research, offering a tool to investigate cell death pathways and their implications in various biological processes and disease models.
- IUPAC
- 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone,5-(Indol-3-ylmethyl)-3-methyl-2-thio-Hydantoin,MTH-DL-Tryptophan
- Synonyms
- 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone5-(Indol-3-ylmethyl)-3-methyl-2-thio-HydantoinMTH-DL-Tryptophan
Necroptosis Inhibition Research
Necrostatin-1 serves as a key research tool for studying the mechanisms of necroptosis, a regulated form of necrosis. It allows scientists to probe the role of this cell death pathway in physiological and pathological conditions.
Cell Signaling Investigations
As a modulator of cell signaling, Necrostatin-1 aids in understanding complex cellular communication networks. Its use can elucidate signalling cascades involved in cell survival, death, and inflammation.
Neuroscience Research Applications
This compound finds application in neuroscience research for investigating the role of necroptosis in neuronal survival and death. This is critical for understanding neurodegenerative diseases and brain injury.
Bioactive Small Molecule Studies
Necrostatin-1 is utilised as a bioactive small molecule to study cellular responses. Researchers employ it to observe the downstream effects of inhibiting specific cell death pathways.
| Molecular weight | 259.33 |
|---|---|
| Empirical formula | C13H13N3OS |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Necrostatin-1 used for?
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Necrostatin-1 is primarily used in research as an inhibitor of programmed necrosis (necroptosis). It is a tool for studying cell death pathways, cell signaling, and has applications in neuroscience and broader cell biology research.
What are the CAS number and chemical formula for Necrostatin-1?
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The CAS number for Necrostatin-1 is 4311-88-0 and its empirical formula is C13H13N3OS.
What grade and purity does Tech Serve Solutions supply for Necrostatin-1?
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Tech Serve Solutions supplies Necrostatin-1 with a purity of ≥98% (HPLC). This product is intended for research and laboratory use only, and is not represented as USP, BP, EP, or pharmacopoeia grade.
What safety precautions should be taken when handling Necrostatin-1?
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When handling Necrostatin-1, it is essential to use personal protective equipment including eyeshields and gloves. A respirator filter, such as type N95 (US) or type P1 (EN143), should be used. The WGK Germany classification is 3.
How is Necrostatin-1 supplied and exported by TSS?
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Necrostatin-1 is supplied as a powder and stored at -20°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample of Necrostatin-1?
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To request a quote or sample of Necrostatin-1, please contact our sales team through the website or via direct inquiry. Details for specific quantities and packaging can be discussed.
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