Nebivolol hydrochloride
Nebivolol hydrochloride (CAS: 152520-56-4), with the molecular formula C22H25F2NO4·HCl, is a white to off-white powder. As a selective beta-1 adrenergic receptor antagonist, it primarily functions as a cardiovascular therapeutic agent. Its pharmacological profile allows for vasodilation and reduced heart rate, making it valuable in managing hypertension and related conditions. Tech Serve Solutions supplies this compound for research and development purposes.
- IUPAC
- Narbivolol,Nebilet,R-65824,rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
- Synonyms
- NarbivololNebiletR-65824rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
Cardiovascular Research
Nebivolol hydrochloride is utilized in preclinical research to investigate its effects on blood pressure, heart rate, and vascular function. Its selective beta-1 antagonism and nitric oxide-mediated vasodilation properties make it a key compound for studying cardiovascular pathways.
Pharmacological Studies
This compound serves as a reference standard or research tool in studies focused on adrenergic receptor pharmacology. Researchers use it to elucidate mechanisms of action related to beta-blockade and its impact on physiological systems.
Drug Discovery and Development
Nebivolol hydrochloride can be employed in early-stage drug discovery programs exploring novel cardiovascular agents or investigating drug interactions. Its known pharmacological profile aids in the design and validation of new therapeutic strategies.
| Empirical formula | C22H25F2NO4 · HCl |
|---|---|
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: ≥20 mg/mL |
| Storage temperature | room temp |
Hazard statements
- H302Harmful if swallowed
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P501Dispose of contents and container per local regulations
| Transport (UN / ADR) | UN 3077 9 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-50/53 |
| Safety statements (S) | 60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | desiccated |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nebivolol hydrochloride used for?
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Nebivolol hydrochloride is primarily used in research settings to study cardiovascular physiology, adrenergic receptor pharmacology, and as a tool in drug discovery and development, particularly for cardiovascular conditions.
What is the CAS number and molecular formula for Nebivolol hydrochloride?
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The CAS number is 152520-56-4, and the molecular formula is C22H25F2NO4·HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nebivolol hydrochloride with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade unless explicitly stated in the product documentation.
How should Nebivolol hydrochloride be handled?
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Nebivolol hydrochloride is classified as a Warning, with hazards including H302 (Harmful if swallowed) and H410 (Very toxic to aquatic life with long lasting effects). Handle with appropriate personal protective equipment in a well-ventilated area, avoiding release into the environment. Store desiccated at room temperature.
Is Nebivolol hydrochloride a controlled substance?
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The provided data does not indicate that Nebivolol hydrochloride is a controlled substance. However, users should always comply with local regulations.
How is Nebivolol hydrochloride packed and exported?
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Nebivivolol hydrochloride is typically supplied as a powder. For export, it is packaged to comply with international shipping regulations, including UN 3077 (9 / PGIII) for environmental hazards.
How can I request a quote or sample for Nebivolol hydrochloride?
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To request a quote or sample for Nebivolol hydrochloride, please contact our sales team through the website or by direct inquiry, providing your specific requirements.
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