Necrostatin-5
Necrostatin-5 (CAS: 337349-54-9) is a thienopyrimidine derivative with the molecular formula C19H17N3O2S2 and a molecular weight of 383.49 g/mol. Supplied as a white to off-white solid, this compound is primarily utilised in research settings for its role in apoptosis and cell cycle studies. Its applications extend to cell biology and cell signalling investigations, making it a valuable reagent for scientists exploring these complex biological pathways.
- IUPAC
- 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile,3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
Apoptosis and Cell Cycle Research
Necrostatin-5 serves as a key tool for researchers investigating the mechanisms of programmed cell death (apoptosis) and the regulation of the cell cycle. Its chemical properties allow for detailed study of cellular processes at a molecular level.
Cell Biology Investigations
This compound is employed in various cell biology research applications, aiding in the understanding of cellular functions and responses. It is particularly useful for experiments focused on cell signalling pathways.
Bioactive Small Molecule Studies
As a bioactive small molecule, Necrostatin-5 is utilised in screening and validation studies to explore its pharmacological effects and potential therapeutic targets within biological systems.
| Molecular weight | 383.49 |
|---|---|
| Empirical formula | C19H17N3O2S2 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white to off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H319Causes serious eye irritation
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Necrostatin-5 used for?
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Necrostatin-5 is used in research for studying apoptosis, cell cycle regulation, cell biology, and cell signalling. It is a bioactive small molecule for scientific investigation.
What is the CAS number and molecular formula for Necrostatin-5?
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The CAS number for Necrostatin-5 is 337349-54-9, and its molecular formula is C19H17N3O2S2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Necrostatin-5 with an assay of ≥98% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Necrostatin-5 be handled safely?
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Necrostatin-5 is a Warning substance (GHS07) and may cause eye irritation (H319) and potentially harmful long-term effects to aquatic life (H413). Handle with appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation.
How is Necrostatin-5 packaged and shipped?
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Necrostatin-5 is supplied as a white to off-white solid and is typically stored at 2-8°C. Tech Serve Solutions exports chemicals globally, adhering to all necessary shipping regulations.
How can I request a sample or quote for Necrostatin-5?
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To request a sample or a quotation for Necrostatin-5, please contact our sales department through the website or by calling our main office.
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