N-Boc-piperidine-2-methanol
N-Boc-piperidine-2-methanol (CAS: 157634-00-9, C11H21NO3) is a valuable heterocyclic building block with a molecular weight of 215.29 g/mol. This compound serves as a key reactant in various organic syntheses, including the preparation of complex pharmaceuticals and novel heterocyclic compounds. Its protected piperidine structure makes it a versatile intermediate for advanced chemical research and development, facilitating intricate synthetic pathways.
- IUPAC
- 2-Hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester,N-Boc-2-(hydroxymethyl)piperidine
- Synonyms
- 2-Hydroxymethylpiperidine-1-carboxylic acid tert-butyl esterN-Boc-2-(hydroxymethyl)piperidine
Julia Coupling Reactions
Serves as a reactant in Julia coupling reactions, notably in the synthesis of complex natural products like corydendramine A. This application highlights its utility in constructing specific carbon-carbon bonds.
Cyclization Strategies
Employed in the cyclization-functionalization of nitrogen-containing dienes, enabling the formation of complex cyclic structures. This is crucial for building diverse molecular architectures.
Heterocyclic Compound Synthesis
A useful building block for the synthesis of a wide array of heterocyclic compounds. Its structure is well-suited for incorporation into various ring systems.
Pharmaceutical Intermediate
Utilised in the synthesis of advanced pharmaceutical agents, such as anthranilamide inhibitors of factor Xa, human GnRH receptor antagonists, and sphingosine-1-phosphate receptor agonists.
| Molecular weight | 215.29 |
|---|---|
| Empirical formula | C11H21NO3 |
| Assay | 97% |
| Application | Reactant for:• Julia coupling for synthesis of corydendramine A1• Cyclization-functionalization of nitrogen-containing dienes2Reactant for synthesis of:• Heterocyclic compounds3• Anthranilamide inhibitors of factor Xa4• Human GnRH receptor antagonists5• Sphingosine-1-phosphate receptor agonists6 |
| Melting point | 74-78 °C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-piperidine-2-methanol used for?
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N-Boc-piperidine-2-methanol is primarily used as a reactant and building block in organic synthesis. It is integral to the preparation of various heterocyclic compounds, natural products like corydendramine A, and pharmaceutical agents including factor Xa inhibitors, GnRH receptor antagonists, and sphingosine-1-phosphate receptor agonists.
What is the CAS number and formula for N-Boc-piperidine-2-methanol?
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The CAS number is 157634-00-9, and its empirical formula is C11H21NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Boc-piperidine-2-methanol with a minimum assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade; it is supplied for research and chemical synthesis purposes.
How should N-Boc-piperidine-2-methanol be handled safely?
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N-Boc-piperidine-2-methanol is classified as Danger. It is harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment including eyeshields, face shields, gloves, and a type P2 respirator. Ensure good ventilation.
Is N-Boc-piperidine-2-methanol a controlled substance?
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The provided data does not indicate that N-Boc-piperidine-2-methanol is a controlled substance.
How is N-Boc-piperidine-2-methanol packed and exported?
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N-Boc-piperidine-2-methanol is packed and shipped in accordance with UN 2811, Class 6.1, Packing Group III regulations, ensuring safe transport globally as a fine chemical supplier and exporter.
How can I request a sample or quote for N-Boc-piperidine-2-methanol?
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To request a sample or a quotation for N-Boc-piperidine-2-methanol, please use the 'Contact Us' form or email our sales department, referencing the product name and CAS number.
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