Fmoc chloride
9-Fluorenylmethoxycarbonyl chloride (Fmoc-Cl), CAS 28920-43-6, with the molecular formula C15H11ClO2 and a molecular weight of 258.70 g/mol, is a critical reagent primarily utilised in organic synthesis. It serves as an essential protecting group in peptide chemistry, facilitating the selective derivatisation of amino acids for complex molecular construction. Its utility extends to analytical applications requiring precise sample modification.
- IUPAC
- 9-Fluorenylmethoxycarbonyl chloride,9-Fluorenylmethyl chloroformate,Fmoc-Cl
- Synonyms
- 9-Fluorenylmethoxycarbonyl chloride9-Fluorenylmethyl chloroformateFmoc-Cl
Peptide Synthesis
Fmoc-Cl is widely employed as a protecting group for the amine function in amino acids during solid-phase peptide synthesis (SPPS). This enables the sequential addition of amino acids to build peptide chains.
Amino Acid Derivatisation
It is used as a reagent for derivatising amino acids, which is crucial for their analysis via High-Performance Liquid Chromatography (HPLC). This process enhances detection and separation.
Organic Synthesis Reagent
Beyond peptide chemistry, Fmoc-Cl acts as a versatile reagent in various organic synthesis pathways where the introduction of the Fmoc protecting group is required.
| Molecular weight | 258.70 |
|---|---|
| Empirical formula | C15H11ClO2 |
| Assay | ≥98.0% (HPLC) |
| Grade | purum |
| Storage temperature | 2-8°C |
| Application | Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis. |
| Melting point | 61-63 °C62-64 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc chloride primarily used for?
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Fmoc chloride (CAS 28920-43-6) is primarily used as a reagent for protecting amine groups, especially in the synthesis of peptides and for derivatising amino acids for analysis.
What is the CAS number and formula for Fmoc chloride?
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The CAS number for Fmoc chloride is 28920-43-6, and its empirical formula is C15H11ClO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc chloride with a purity of ≥98.0% (HPLC), conforming to the 'purum' grade. We do not represent this product as USP, BP, or EP grade.
How should Fmoc chloride be handled and stored?
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Fmoc chloride is a corrosive substance (H314) and requires careful handling with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection. It should be stored at 2-8°C.
Is Fmoc chloride a controlled substance?
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The provided data does not indicate that Fmoc chloride is a controlled substance.
How is Fmoc chloride packed and exported?
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Fmoc chloride is shipped according to ADR regulations as UN 3261, Class 8, Packing Group II, reflecting its hazardous nature for safe global export.
How can I request a sample or quote for Fmoc chloride?
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Please contact our sales team through the website or by phone to request a sample or a quotation for Fmoc chloride.
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