Fmoc isothiocyanate
Fmoc isothiocyanate (CAS: 199915-38-3), with the molecular formula C16H11NO2S and a molecular weight of 281.33 g/mol, is a key reagent primarily used for amine protection. It is crucial in synthetic organic chemistry, particularly in peptide synthesis and the modification of biomolecules. This compound facilitates the introduction of the Fmoc protecting group onto amine functionalities, enabling controlled chemical transformations.
- IUPAC
- 9-Fluorenylmethoxycarbonyl isothiocyanate,9-Fluorenylmethyl isothiocyanatoformate
- Synonyms
- 9-Fluorenylmethoxycarbonyl isothiocyanate9-Fluorenylmethyl isothiocyanatoformate
Amine Protection in Peptide Synthesis
Fmoc isothiocyanate is widely employed in solid-phase peptide synthesis (SPPS) to introduce the base-labile Fmoc protecting group onto amino acids. This protection strategy is essential for the sequential coupling of amino acids, preventing unwanted side reactions during peptide chain elongation.
Bioconjugation and Chemical Biology
This reagent is valuable in chemical biology for modifying proteins and other biomolecules. The isothiocyanate group reacts readily with amine functionalities on biological targets, allowing for the introduction of the Fmoc group for subsequent derivatization or for use as a fluorescent label precursor.
Synthesis of Modified Amino Acids and Peptides
Fmoc isothiocyanate serves as a building block for creating novel amino acid derivatives and modified peptides. Its reactivity allows for the preparation of complex structures used in drug discovery and materials science research.
Organic Synthesis Reagent
Beyond peptide chemistry, Fmoc isothiocyanate finds application in general organic synthesis for introducing the Fmoc moiety onto various amine-containing substrates. This enables selective functionalization and the construction of complex organic molecules.
| Molecular weight | 281.33 |
|---|---|
| Empirical formula | C16H11NO2S |
| Assay | ≥85% (coupling to amines)≥98.0% (CHN) |
| Solubility | ethanol: soluble |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41 |
| Safety statements (S) | 36/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 264 nm; λem 313 nm |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc isothiocyanate used for?
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Fmoc isothiocyanate (CAS: 199915-38-3) is primarily used for amine protection, particularly in peptide synthesis and chemical biology applications. It introduces the Fmoc protecting group onto amine functionalities.
What are the CAS number and formula for Fmoc isothiocyanate?
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The CAS number for Fmoc isothiocyanate is 199915-38-3, and its molecular formula is C16H11NO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc isothiocyanate with an assay of ≥85% for coupling to amines and ≥98.0% (CHN). This product is supplied for research and development purposes and is not represented as USP, BP, EP, or other pharmacopoeial grades.
How should Fmoc isothiocyanate be handled safely?
+
Fmoc isothiocyanate is classified as a Danger. It causes skin irritation (H315), serious eye damage (H318), and may cause respiratory irritation (H335). Appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves should be used. Handle in a well-ventilated area or fume hood.
How is Fmoc isothiocyanate shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Fmoc isothiocyanate is typically stored at -20°C and can be shipped and exported worldwide, adhering to all relevant regulations.
How can I request a sample or quote for Fmoc isothiocyanate?
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To request a sample or a quote for Fmoc isothiocyanate, please contact the Tech Serve Solutions sales team through our website or by phone. Provide the product name and CAS number (199915-38-3) for prompt service.
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