N-Acetyl-2-oxindole
N-Acetyl-2-oxindole (CAS 21905-78-2) is a crystalline heterocyclic building block with the molecular formula C10H9NO2 and a molar mass of 175.18 g/mol. It is the N-acetylated derivative of 2-oxindole, melting at 127-131 degC, and is supplied at 97% assay for research and chemical synthesis. The active methylene and indolinone framework make it a versatile reactant in the construction of fused indole and ellipticine-type scaffolds. Tech Serve Solutions supplies and exports this oxindole intermediate to laboratories worldwide.
- IUPAC
- 1-Acetyl-1,3-dihydro-indol-2-one,N-Acetyloxindole,NSC 286428
- Synonyms
- N-Acetyl-2-oxindole1-Acetyl-1,3-dihydro-indol-2-oneN-Acetyloxindole1-Acetyl-2-oxindole1-Acetylindolin-2-one1-Acetyl-1,3-dihydro-2H-indol-2-oneNSC 286428
Ellipticine analogue synthesis
Used as a reactant in the preparation of 4-azachromeno[2,3-b]indol-11(6H)-ones and related derivatives studied as analogues of the alkaloid ellipticine.
Indolopyrrolopyran construction
Serves as a reactant for the synthesis of indolopyrrolopyrans through solid-supported, microwave-accelerated tandem intramolecular Knoevenagel/hetero-Diels-Alder reactions.
Phytoalexin and antifungal research
Employed in the synthesis of phytoalexins and their analogues via Vilsmeier formylation-amination, investigated for antifungal activity.
Heterocyclic building block
The reactive indolin-2-one core with an N-acetyl group functions as a C10 building block for assembling fused indole and oxindole heterocycles in medicinal and synthetic chemistry.
| Molecular weight | 175.18 |
|---|---|
| Empirical formula | C10H9NO2 |
| Assay | 97% |
| Application | • Reactant for preparation of 4-azachromeno[2,3-b]indol-11(6H)-ones and derivatives as analogs of ellipticine1• Reactant for preparation of indolopyrrolopyrans by solid-supported microwave-accelerated tandem intramolecular Knoevenagel/hetero Diels-Alder reaction2• Reactant for synthesis of phytoalexins and analogs via Vilsmeier formylation-amination as antifungal agents3 |
| Melting point | 127-131 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Acetyl-2-oxindole used for?
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N-Acetyl-2-oxindole is used as a heterocyclic building block in chemical synthesis. Documented uses include preparing ellipticine analogues such as 4-azachromeno[2,3-b]indol-11(6H)-ones, synthesising indolopyrrolopyrans by tandem Knoevenagel/hetero-Diels-Alder reactions, and making phytoalexins investigated as antifungal agents. It is intended for research and manufacturing use.
What is the CAS number and molecular formula of N-Acetyl-2-oxindole?
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The CAS number is 21905-78-2 and the molecular formula is C10H9NO2 (Hill notation), corresponding to a molecular weight of 175.18 g/mol. The MDL number is MFCD00187672. It is also known as 1-acetyl-1,3-dihydro-indol-2-one and N-acetyloxindole.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Acetyl-2-oxindole at a typical assay of 97% as a research and synthesis-grade material, with a reported melting point of 127-131 degC. We do not represent it as USP, BP or EP pharmacopoeia grade. A certificate of analysis can be provided with each batch on request.
How should N-Acetyl-2-oxindole be handled and stored?
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Handle as a laboratory chemical using good practice: wear eye protection and gloves and, where dust may form, a type N95 (US) or P1 (EN143) respirator filter. The material carries a German water hazard class of WGK 3, meaning it is severely hazardous to water, so prevent release to drains and the environment. Always consult the current Safety Data Sheet before use.
How is N-Acetyl-2-oxindole packed, shipped and exported?
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It is packed as a solid in tightly closed, labelled containers sized to your requirements, from gram research quantities to larger commercial lots. Tech Serve Solutions exports globally with full documentation, including a certificate of analysis and Safety Data Sheet, and packaging compliant with applicable transport regulations.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name, CAS number 21905-78-2 and your required quantity and purity. We will confirm availability, lead time and export documentation, and can arrange a sample where appropriate for evaluation.
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