N-Benzyl-3-hydroxypiperidine
N-Benzyl-3-hydroxypiperidine (CAS 14813-01-5; C12H17NO; molar mass 191.27 g/mol) is an N-benzyl-protected hydroxypiperidine used as a heterocyclic building block in fine-chemical and pharmaceutical synthesis. The benzyl group masks the ring nitrogen while the secondary 3-hydroxyl offers a handle for further functionalisation, making it a versatile intermediate. Tech Serve Solutions supplies it at 97% assay to research, discovery and process-development laboratories worldwide as a reliable specialist partner.
- IUPAC
- 1-(Phenylmethyl)-3-piperidinol,1-Benzyl-3-hydroxypiperidine
- Synonyms
- N-Benzyl-3-hydroxypiperidine1-Benzyl-3-hydroxypiperidine1-(Phenylmethyl)-3-piperidinol1-Benzyl-3-piperidinol1-Benzylpiperidin-3-ol
Heterocyclic building block
Serves as a 3-substituted piperidine scaffold in multistep organic synthesis. The N-benzyl group acts as a removable protecting group on the ring nitrogen while the 3-hydroxyl supports oxidation, substitution or coupling steps.
Pharmaceutical intermediate
Used as a reactant in the synthesis of biologically active piperidine compounds, including reported routes to muscarinic M3 selective antagonists and Rho kinase inhibitors. It is intended for research and manufacturing use, not for direct therapeutic application.
Receptor and medicinal-chemistry research
Applied as a precursor to piperidine derivatives prepared for investigations into alpha-adrenoreceptor activation and related structure-activity studies. The defined scaffold supports systematic exploration of analogue series.
Biocatalysis and chiral resolution studies
Reported as a reactant in the bioresolution of tertiary amino ester protic ionic liquids using subtilisin. The compound bears a stereocentre at the 3-position, making it relevant to enzymatic and chiral-resolution work.
| Molecular weight | 191.27 |
|---|---|
| Empirical formula | C12H17NO |
| Assay | 97% |
| Refractive index | n20/D 1.549 |
| Application | Reactant for bioresolution of tertiary amino ester protic ionic liquids using subtilisin1Reactant for synthesis of:• Muscarinic M3 selective antagonists2• Rho kinase inhibitors3• Piperidine derivatives for investigations into α-adrenoreceptor direct activation4 |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Benzyl-3-hydroxypiperidine used for?
+
It is used primarily as a heterocyclic building block and pharmaceutical intermediate in organic synthesis. Documented uses include the preparation of muscarinic M3 selective antagonists, Rho kinase inhibitors and piperidine derivatives for receptor research, as well as biocatalytic resolution studies. It is supplied for research and manufacturing use only.
What is the CAS number and molecular formula of N-Benzyl-3-hydroxypiperidine?
+
The CAS number is 14813-01-5 and the molecular formula is C12H17NO, with a molecular weight of 191.27 g/mol. Additional identifiers include EC number 238-881-0 and MDL number MFCD00023734.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies N-Benzyl-3-hydroxypiperidine at a typical assay of 97%, with a refractive index of n20/D 1.549. It is offered as a research and technical grade material; we do not represent it as USP, BP or EP pharmacopoeial grade. A certificate of analysis can be provided on request.
What are the safety and handling requirements for N-Benzyl-3-hydroxypiperidine?
+
It is classified under GHS with the signal word Danger and pictogram GHS06. The hazard statements are H301 (toxic if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with eye and face protection, gloves and a type P2 respirator where required, and consult the full SDS before use.
How is N-Benzyl-3-hydroxypiperidine packed, shipped and exported?
+
It is packed in appropriate inert, well-sealed containers with sizes from gram quantities to bulk, each labelled and accompanied by documentation. For transport it is classified as UN 2811, Class 6.1, Packing Group III, and is shipped internationally in compliance with applicable dangerous-goods regulations.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, purity and destination, and our team will confirm availability, lead time and documentation. Samples and quotations are arranged for qualified research and industrial customers.
▶ Related products
4-Amino-2-chloropyridine
C5H5ClN2
Heterocyclic Building Blocks
4-Ethynyl-1-methyl-1H-pyrazole
C6H6N2
Heterocyclic Building Blocks
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
C12H11NO3
Heterocyclic Building Blocks
4-isocyanatopyridine
C6H4N2O
Heterocyclic Building Blocks
5-Chloro-2,8-dimethylquinoline
Heterocyclic Building Blocks
5-Chloro-2-methylene-1,3,3-trimethylindoline
Heterocyclic Building Blocks
5-Chloro-2-thiophenecarbonitrile
Heterocyclic Building Blocks
5-ethynyl-1H-pyrazole
C5H4N2
Heterocyclic Building Blocks▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis