N-(6-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide
N-(6-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide (CAS 851102-44-8; C10H13IN2O; molar mass 304.13 g/mol) is a halogenated pyridine building block in which a 6-iodopyridin-2-amine carries a pivaloyl (2,2-dimethylpropionamide) group on nitrogen. The reactive carbon-iodine bond and the protected amino function make it a versatile intermediate for transition-metal cross-coupling and directed functionalisation in pharmaceutical and fine-chemical synthesis. Tech Serve Solutions supplies it as a research-grade synthesis reagent for laboratory and process development use.
- Synonyms
- N-(6-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamideN-(6-Iodopyridin-2-yl)pivalamide2,2-Dimethyl-N-(6-iodopyridin-2-yl)propanamideN-(6-Iodo-2-pyridinyl)-2,2-dimethylpropanamide6-Iodo-2-pivaloylaminopyridineCAS 851102-44-8
Cross-coupling intermediate
The aryl-iodide site is well suited to palladium-catalysed cross-coupling reactions such as Suzuki-Miyaura, Negishi, Stille and Sonogashira, enabling carbon-carbon bond formation to extend the pyridine scaffold. This makes the compound a convenient handle for building more complex heteroaromatic targets.
Pharmaceutical building block
As a substituted 2-aminopyridine derivative, it serves as a heterocyclic building block in the synthesis of pharmaceutical intermediates and candidate molecules. The pivalamide-protected amine allows the amino group to be revealed or further elaborated at a later stage.
Directed C-H functionalisation
The pivaloyl amide can act as a directing group in metalation and transition-metal-catalysed C-H functionalisation chemistry, supporting regioselective introduction of substituents on the pyridine ring during methodology and route development.
Halogenated heterocycle for discovery chemistry
Within medicinal and agrochemical discovery programmes, this iodopyridine is used to assemble libraries and analogues where a pyridine core and a single, selectively reactive halogen are required.
Reference and method development
It is employed as a defined small-molecule reagent for synthetic methodology studies and analytical method development in research laboratories.
| Molecular weight | 304.13 |
|---|---|
| Empirical formula | C10H13IN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(6-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide used for?
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It is used as a halogenated pyridine building block in chemical synthesis. The reactive carbon-iodine bond supports palladium-catalysed cross-coupling reactions (such as Suzuki, Negishi, Stille and Sonogashira), while the pivalamide-protected 2-aminopyridine core makes it useful for preparing pharmaceutical intermediates and for directed functionalisation in research and process chemistry.
What is the CAS number and molecular formula of N-(6-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide?
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The CAS number is 851102-44-8 and the molecular formula is C10H13IN2O, with a molecular weight of 304.13 g/mol. It is a pyridine derivative bearing an iodo substituent and an N-pivaloyl (2,2-dimethylpropionamide) group.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research/technical-grade synthesis reagent. Specific assay data can be confirmed against the batch certificate of analysis at the time of enquiry. We do not represent this item as USP, BP or EP pharmacopoeial grade.
How should N-(6-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide be handled and stored?
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Handle as a laboratory chemical under good laboratory practice: use appropriate personal protective equipment, work in a well-ventilated area or fume hood, and avoid generating dust and contact with skin, eyes and clothing. Store in a tightly closed container in a cool, dry place away from incompatible materials. As with many organoiodine compounds, protection from prolonged light and heat is advisable. Refer to the current Safety Data Sheet supplied with the product for full hazard and first-aid information.
How is N-(6-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
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It is packed in sealed, appropriately labelled containers sized to the order, from gram quantities to larger research and bulk requirements. Tech Serve Solutions exports worldwide with complete documentation, including the certificate of analysis and Safety Data Sheet, and arranges packaging and transport in line with applicable regulations for the destination market.
How do I request a sample or quote?
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Contact Tech Serve Solutions with the product name or CAS number 851102-44-8 and your required quantity and specification. Our team will confirm availability, batch details and lead time and provide a formal quotation, along with a sample where appropriate.
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