N-(Benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine
N-(Benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine (CAS 152120-62-2; C12H12N4O2; molar mass 244.25 g/mol) is a crystalline heterocyclic building block used as a guanidinylating reagent in chemical synthesis. The Cbz (benzyloxycarbonyl) group offers a protected, orthogonally removable handle for installing mono-protected guanidine functions onto primary and secondary amines. Tech Serve Solutions supplies it at 97% assay as a research and laboratory reagent for pharmaceutical intermediate and fine-chemical synthesis.
- IUPAC
- Benzyl N-[imino(1-pyrazolyl)methyl]carbamate,Z-1H-pyrazole-1-carboxamidine
- Synonyms
- N-(Benzyloxycarbonyl)-1H-pyrazole-1-carboxamidineBenzyl N-[imino(1-pyrazolyl)methyl]carbamateZ-1H-pyrazole-1-carboxamidineN-Cbz-1H-pyrazole-1-carboxamidineN-Benzyloxycarbonyl-1H-pyrazole-1-carboxamidine
Guanidinylation of amines
Acts as a reactive guanidinylating reagent, transferring an amidine unit to primary and secondary amines to form Cbz-protected guanidines. The 1-pyrazolyl group serves as the leaving group during this transformation.
Protected guanidine installation
The benzyloxycarbonyl (Cbz/Z) group provides a mono-protected guanidine that can be revealed later under standard deprotection conditions, supporting controlled, selective synthetic sequences.
Pharmaceutical intermediate synthesis
Used as a building block in the preparation of guanidine-containing intermediates and active pharmaceutical ingredient candidates where a protected amidine motif is required.
Heterocyclic and fine-chemical research
Serves as a versatile C12-class heterocyclic building block in medicinal-chemistry and discovery programmes that target guanidine, amidine and related nitrogen-rich scaffolds.
| Molecular weight | 244.25 |
|---|---|
| Empirical formula | C12H12N4O2 |
| Assay | 97% |
| Melting point | 106-110 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(Benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine used for?
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It is used as a guanidinylating reagent in chemical synthesis. It transfers an amidine unit to primary and secondary amines, installing a benzyloxycarbonyl (Cbz/Z) protected guanidine group, and is applied in pharmaceutical intermediate and fine-chemical research.
What is the CAS number and molecular formula of N-(Benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine?
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The CAS number is 152120-62-2 and the molecular formula is C12H12N4O2, with a molecular weight of 244.25 g/mol (MDL number MFCD00274657). It is a crystalline solid with a melting point of 106–110 °C (lit.).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at 97% assay as a research and laboratory reagent grade. We do not represent it as USP, BP or EP pharmacopoeia grade. A Certificate of Analysis is provided with each batch.
What are the safety and handling requirements?
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It is classified GHS07 with the signal word Warning. Hazard statements are H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust formation, and follow the precautionary advice P261 and P305+P351+P338. WGK Germany water-hazard class is 3.
How is N-(Benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine packed, shipped and exported?
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It is packed as a solid in tightly closed, labelled containers sized to your requirement, from laboratory quantities to bulk. Tech Serve Solutions exports globally with full documentation, including a Certificate of Analysis and Safety Data Sheet, under appropriate transport and customs handling.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, purity and delivery destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation where applicable.
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