N-(6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl)pivalamide
N-(6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl)pivalamide (CAS 1186310-88-2; C15H21IN2O2Si; molar mass 416.33 g/mol) is a multifunctional furo[3,2-b]pyridine building block. It combines an aryl iodide, a 2-trimethylsilyl group and a pivalamide-protected amine on a fused furopyridine core, making it a versatile intermediate for cross-coupling, directed functionalisation and medicinal-chemistry scaffold assembly. Tech Serve Solutions supplies it as a research-grade reagent for synthesis laboratories worldwide.
- Synonyms
- N-(6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl)pivalamideN-[6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl]-2,2-dimethylpropanamide6-Iodo-2-(trimethylsilyl)-7-pivalamidofuro[3,2-b]pyridineCAS 1186310-88-2
![N-(6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl)pivalamide (C15H21IN2O2Si) — chemical structure, CAS 1186310-88-2; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1186310-88-2.png&w=3840&q=75)
Cross-coupling and metal-catalysed functionalisation
The 6-iodo substituent provides a reactive handle for palladium- and copper-catalysed couplings such as Suzuki, Sonogashira, Negishi and Buchwald-Hartwig reactions, enabling controlled elaboration of the furopyridine core.
Heterocyclic building block for medicinal chemistry
As a furo[3,2-b]pyridine scaffold carrying multiple orthogonal handles, it is used to construct fused-heterocyclic libraries and pharmaceutical intermediates during early-stage discovery and structure-activity studies.
Organosilicon chemistry
The 2-trimethylsilyl group can serve as a directing or blocking group and as a site for protodesilylation or silicon-based transformations, supporting regioselective routes on the furopyridine ring.
Protected-amine intermediate
The pivalamide masks the 7-amino position, allowing selective chemistry elsewhere on the molecule before deprotection to reveal the free amine for further derivatisation.
Reference and research-scale synthesis
Supplied for laboratory research, method development and reference use where a defined halogenated, silyl-functionalised furopyridine building block is required.
| Molecular weight | 416.33 |
|---|---|
| Empirical formula | C15H21IN2O2Si |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl)pivalamide used for?
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It is used as a synthetic building block in organic and medicinal chemistry. Its aryl iodide enables metal-catalysed cross-coupling, its trimethylsilyl group supports regioselective functionalisation, and its pivalamide protects the ring amine, making the compound a versatile intermediate for assembling furo[3,2-b]pyridine scaffolds.
What is the CAS number and molecular formula of N-(6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl)pivalamide?
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The CAS number is 1186310-88-2. The empirical formula (Hill notation) is C15H21IN2O2Si, with a molecular weight of 416.33 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research/technical-grade reagent for laboratory synthesis. A certificate of analysis with the batch assay can be provided on request. We do not represent it as USP, BP or EP pharmacopoeial grade.
What safety and handling precautions apply?
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No GHS classification data is included in our current product record, so the material should be treated as a research chemical of undefined hazard. Handle only with appropriate gloves, eye protection and ventilation, avoid dust, skin and eye contact, and follow good laboratory practice. Always consult the Safety Data Sheet, which is available on request, before use.
How is N-(6-Iodo-2-(trimethylsilyl)furo[3,2-b]pyridin-7-yl)pivalamide packed, shipped and exported?
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It is packed in suitably sealed laboratory containers with full batch labelling and accompanying documentation. As an iodinated, silyl-functionalised compound it is typically stored cool and dry; Tech Serve Solutions arranges compliant domestic and international export shipping with the relevant paperwork.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity and destination, and we will confirm availability, packaging, lead time and a quotation. Samples and a certificate of analysis can be provided on request.
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