Methylguanidine hydrochloride
Methylguanidine hydrochloride (CAS 22661-87-6) is an organic compound with the formula CH3NHC(=NH)NH2·HCl and a molecular weight of 109.56 g/mol. As a guanidine derivative, it serves as a valuable building block in organic synthesis. Its primary application involves its use in the development of biaryl derivatives, which have been investigated for their potential as BACE1 inhibitors in research settings.
Organic Synthesis
Methylguanidine hydrochloride is employed as a key intermediate in the synthesis of more complex organic molecules. Its structure lends itself to various chemical transformations, making it a useful component in multi-step synthetic pathways.
Pharmaceutical Research
This compound has been utilised in the preparation of biaryl derivatives. These derivatives have been evaluated for their biological activity, specifically as potential inhibitors of Beta-secretase 1 (BACE1), a target in neurological research.
Chemical Building Block
Functioning as a versatile building block, Methylguanidine hydrochloride (CAS 22661-87-6) offers a reactive guanidine moiety suitable for constructing novel chemical entities.
| Molecular weight | 109.56 |
|---|---|
| Linear formula | CH3NHC(=NH)NH2·HCl |
| Assay | 98% |
| Solubility | water: soluble50 mg/mL, clear |
| Application | Methylguanidine hydrochloride was used in the synthesis of biaryl derivatives which were evaluated as BACE1 inhibitors1. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methylguanidine hydrochloride used for?
+
Methylguanidine hydrochloride is primarily used as a building block in organic synthesis and in pharmaceutical research for the preparation of biaryl derivatives evaluated as BACE1 inhibitors.
What are the CAS number and formula for Methylguanidine hydrochloride?
+
The CAS number is 22661-87-6 and the chemical formula is CH3NHC(=NH)NH2·HCl.
What grade and purity does Tech Serve Solutions supply for Methylguanidine hydrochloride?
+
Tech Serve Solutions supplies Methylguanidine hydrochloride with a minimum assay of 98%. This product is not supplied as USP, BP, EP, or any pharmacopoeia grade and is intended for research and chemical synthesis purposes only.
How should Methylguanidine hydrochloride be handled safely?
+
Methylguanidine hydrochloride (CAS 22661-87-6) is classified as harmful if swallowed and causes skin and serious eye irritation, and may cause respiratory irritation (H302-H315-H319-H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 or equivalent). Ensure adequate ventilation and avoid inhalation of dust. Refer to the Safety Data Sheet for comprehensive handling information.
How is Methylguanidine hydrochloride shipped by Tech Serve Solutions?
+
Tech Serve Solutions exports and ships chemicals globally. Specific packaging details and shipping methods for Methylguanidine hydrochloride can be provided upon request, adhering to all relevant transportation regulations.
How can I request a sample or quote for Methylguanidine hydrochloride?
+
To request a sample or a quote for Methylguanidine hydrochloride, please contact our sales team through the website or provide your requirements via email. Our team will respond promptly with the necessary information.
▶ Related products
3,4,5-Trimethoxybenzylamine
Organic Building Blocks
3,4-dihydroxyphenylacetone
Organic Building Blocks
3-Fluoro-4-methoxybenzonitrile
C8H6FNO
Organic Building Blocks
4-Ethyltoluene
C2H5C6H4CH3
Organic Building Blocks
Fluoroacetic acid
C2H3FO2
Organic Building Blocks
Methoxyacetaldehyde
C3H6O2
Organic Building Blocks
Methyl 4-acetamido-5-chloro-2-methoxybenzoate
Organic Building Blocks
Methyl 5-bromo-2-iodobenzoate
BrC6H3(I)CO2CH3
Organic Building Blocks▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis