(+)-Dehydroabietylamine
(+)-Dehydroabietylamine (CAS: 1446-61-3, Formula: C20H31N) is a chiral amine derived from dehydroabietic acid. With a molecular weight of 285.47 g/mol, this compound is valuable as a chiral resolving reagent and a building block in asymmetric synthesis. Its specific optical activity and structural characteristics make it suitable for applications in complex molecule synthesis and chemical research.
- IUPAC
- 1,4a-Dimethyl-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenemethylamine
Chiral Resolution
(+)-Dehydroabietylamine serves as an effective chiral resolving agent for separating enantiomers of acidic compounds. It forms diastereomeric salts that can be separated by fractional crystallisation, enabling the isolation of pure stereoisomers.
Asymmetric Synthesis
As a chiral building block, this amine can be incorporated into synthetic strategies requiring stereocontrol. It is employed in the synthesis of complex chiral molecules and as a ligand in asymmetric catalysis.
Chemical Research
The compound is utilized in academic and industrial research laboratories for exploring new synthetic methodologies and developing novel chiral compounds. Its unique structure lends itself to various organic chemistry investigations.
Cancer Metabolism Research
It is noted for its role in studies related to cancer metabolism, specifically as an inhibitor of aerobic glycolysis (the Warburg Effect) and as a Pyruvate Dehydrogenase Kinase (PDK) inhibitor. This makes it relevant for cancer research.
| Molecular weight | 285.47 |
|---|---|
| Empirical formula | C20H31N |
| Assay | 60% |
| Grade | technical grade |
| Refractive index | n20/D 1.546(lit.) |
| Optical activity | [α]20/D +56.1°, c = 2.4 in pyridine |
| Composition | high molecular weight primary amines, 90% |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (+)-Dehydroabietylamine used for?
+
(+)-Dehydroabietylamine is primarily used as a chiral resolving reagent for separating enantiomers and as a chiral building block in asymmetric synthesis. It also finds application in cancer metabolism research as an inhibitor of aerobic glycolysis and PDK.
What are the CAS number and formula for (+)-Dehydroabietylamine?
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The CAS number is 1446-61-3, and the molecular formula is C20H31N.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies technical grade (+)-Dehydroabietylamine with an assay of 60%. This product is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How should (+)-Dehydroabietylamine be handled?
+
Handle with appropriate personal protective equipment, including eyeshields and gloves. Use a multi-purpose combination respirator cartridge or a type ABEK (EN14387) respirator filter. Avoid breathing dust/fume/gas/mist/vapours/spray. Ensure adequate ventilation. This compound may cause skin irritation, eye irritation, and respiratory irritation.
Is (+)-Dehydroabietylamine a controlled substance?
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The provided data does not indicate that (+)-Dehydroabietylamine is a controlled substance.
How is (+)-Dehydroabietylamine packed, shipped, and exported?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals, and products are packed and shipped according to international regulations for chemical transport.
How can I request a sample or quote for (+)-Dehydroabietylamine?
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Please contact our sales team via the website or direct email to request a sample or a formal quotation.
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