(+)-Cinchonine
(+)-Cinchonine (CAS: 118-10-5), a C19H22N2O compound with a molecular weight of 294.39 g/mol, is a vital alkaloid derived from Cinchona bark. It is primarily recognised for its utility as a chiral catalyst and resolving agent in asymmetric synthesis. Its distinct stereochemistry makes it invaluable for the separation of enantiomers and the stereoselective synthesis of complex organic molecules across various chemical disciplines.
- IUPAC
- Cinchonine monohydrochloride dihydrate,NSC 6176
Chiral Catalyst in Asymmetric Synthesis
(+)-Cinchonine serves as an effective chiral catalyst and ligand in numerous asymmetric catalytic reactions. It facilitates the stereoselective formation of chiral products, crucial for the pharmaceutical and fine chemical industries.
Chiral Resolving Agent
This alkaloid is widely employed as a chiral resolving agent for the separation of racemic mixtures. It forms diastereomeric salts with chiral acids, allowing for the isolation of individual enantiomers through fractional crystallisation.
Ligand in Organometallic Chemistry
As a privileged ligand, (+)-Cinchonine can coordinate with metal centres to form catalytically active complexes. These complexes are used in a variety of transformations requiring precise stereochemical control.
| Molecular weight | 294.39 |
|---|---|
| Empirical formula | C19H22N2O |
| Assay | 85% |
| Optical activity | [α]23/D +228°, c = 0.5 in ethanol |
| Impurities tested | ~15% dihydrocinchonine (HPLC) |
| Melting point | 258-260 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H332Harmful if inhaled
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/22 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (+)-Cinchonine used for?
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(+)-Cinchonine is primarily used as a chiral catalyst and resolving agent in asymmetric synthesis for the stereoselective synthesis and resolution of chiral compounds.
What is the CAS number and formula for (+)-Cinchonine?
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The CAS number for (+)-Cinchonine is 118-10-5, and its chemical formula is C19H22N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (+)-Cinchonine with a minimum assay of 85%. This product is suitable for research and chemical synthesis purposes; TSS does not represent it as USP, BP, EP, or pharmacopoeia grade.
What are the safety precautions when handling (+)-Cinchonine?
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(+)-Cinchonine is harmful if swallowed and harmful if inhaled (H302-H332). When handling, use a dust mask (type N95 or equivalent), safety eyeshields, and gloves. Ensure adequate ventilation.
Is (+)-Cinchonine a controlled substance?
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The provided data does not indicate that (+)-Cinchonine is a controlled substance.
How is (+)-Cinchonine packed, shipped, and exported?
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Tech Serve Solutions expertly packs, ships, and exports (+)-Cinchonine globally, adhering to all relevant chemical shipping regulations.
How can I request a quote or sample of (+)-Cinchonine?
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To request a quote or sample of (+)-Cinchonine, please contact our sales team through the website or by phone.
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