L-Pyroglutamic acid
L-Pyroglutamic acid (CAS: 98-79-3; Formula: C5H7NO3) is a chiral cyclic amino acid with a molecular weight of 129.11 g/mol. It serves as a valuable building block in asymmetric synthesis and the development of pharmaceuticals. Its distinct chemical properties make it a useful intermediate in peptide chemistry and for the creation of pyroglutamine derivatives.
- IUPAC
- (S)-(−)-2-Pyrrolidone-5-carboxylic acid,(S)-5-Oxo-2-pyrrolidinecarboxylic acid
- Synonyms
- (S)-(−)-2-Pyrrolidone-5-carboxylic acid(S)-5-Oxo-2-pyrrolidinecarboxylic acid
Asymmetric Synthesis
L-Pyroglutamic acid is employed as a chiral building block in complex organic synthesis. Its defined stereochemistry allows for the construction of enantiomerically pure target molecules.
Pharmaceutical Intermediates
This compound functions as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). It contributes to the structural framework of potential drug candidates.
Peptide Chemistry
In peptide synthesis, L-Pyroglutamic acid can be incorporated to introduce specific structural motifs or to modify peptide properties. It is particularly relevant in the study of pyroglutamine-containing peptides.
Research and Development
Utilised in chemical biology and the development of unnatural amino acid derivatives, L-Pyroglutamic acid supports advanced research endeavours.
| Molecular weight | 129.11 |
|---|---|
| Empirical formula | C5H7NO3 |
| Assay | 97% |
| Solubility | H2O: soluble1 M, clear, colorless |
| Optical activity | [α]20/D −10°, c = 13 in H2O |
| Impurities tested | ≤0.0005% Phosphorus (P) |
| Application | Building block for asymmetric synthesis1 and pharmaceuticals.2 |
| Melting point | 160-163 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
| Cation traces | Al: ≤0.0005%Ca: ≤0.0005%Cu: ≤0.0005%Fe: ≤0.0005%K: ≤0.005%Mg: ≤0.0005%NH4+: ≤0.05%Na: ≤0.005%Pb: ≤0.001%Zn: ≤0.0005% |
| Anion traces | chloride (Cl-): ≤0.05%sulfate (SO42-): ≤0.05% |
| Ignition residue | ≤0.1% |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-Pyroglutamic acid used for?
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L-Pyroglutamic acid is used as a building block for asymmetric synthesis and pharmaceuticals, and in peptide chemistry. It is also used in chemical biology and for creating pyroglutamine derivatives and unnatural amino acid derivatives.
What is the CAS number and molecular formula for L-Pyroglutamic acid?
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The CAS number for L-Pyroglutamic acid is 98-79-3, and its molecular formula is C5H7NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies L-Pyroglutamic acid with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should L-Pyroglutamic acid be handled safely?
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L-Pyroglutamic acid is a warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Use a dust mask type N95 (US), wear eyeshields and gloves. Ensure adequate ventilation.
Is L-Pyroglutamic acid a controlled substance?
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No, L-Pyroglutamic acid is not listed as a controlled substance in the provided safety data.
How is L-Pyroglutamic acid packed and exported?
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L-Pyroglutamic acid is carefully packed to maintain its integrity during transit and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for L-Pyroglutamic acid?
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To request a sample or a quotation for L-Pyroglutamic acid, please contact our sales team through the website or by phone.
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