Hydrocinnamoyl chloride
Hydrocinnamoyl chloride (CAS 645-45-4) is a reactive organic compound with the linear formula C₆H₅CH₂CH₂COCl and a molecular weight of 168.62 g/mol. This acid halide serves as a key building block in organic synthesis. It is primarily utilised in the chemical industry for specialised synthetic routes, including the preparation of complex organic molecules and pharmaceutical intermediates, demanding careful handling due to its corrosive nature.
- IUPAC
- 3-Phenylpropionyl chloride
- Synonyms
- 3-Phenylpropionyl chloride
Antifouling Agent Synthesis
Hydrocinnamoyl chloride has been employed in the enantioselective synthesis of (+)-maculalactone A, a compound recognised for its antifouling properties. This application highlights its utility in the development of specialised marine chemicals.
Peptide and Ester Synthesis
The compound is used in the synthesis of hydrocinnamoyl-farnesyl-L-cysteine methyl ester. This demonstrates its role in constructing more complex molecules with potential biological relevance.
Organic Synthesis Intermediate
As a functionalised acid chloride, Hydrocinnamoyl chloride is a valuable intermediate for introducing the 3-phenylpropionyl moiety into various organic structures. It is suitable for reactions requiring acylation.
| Molecular weight | 168.62 |
|---|---|
| Linear formula | C6H5CH2CH2COCl |
| Assay | 98% |
| Boiling point | 107 °C/11 mmHg(lit.) |
| Density | 1.135 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5265(lit.) |
| Application | Hydrocinnamoyl chloride has been used in:• enantioselective synthesis of the antifouling agent, (+)-maculalactone A1• synthesis of hydrocinnamoyl-farnesyl-L-cysteine methyl ester2 |
| Melting point | −7-−5 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 108 °C / 226.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 20-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Hydrocinnamoyl chloride used for?
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Hydrocinnamoyl chloride is used as a building block in organic synthesis, notably in the enantioselective synthesis of antifouling agents like (+)-maculalactone A and in the synthesis of hydrocinnamoyl-farnesyl-L-cysteine methyl ester.
What are the CAS number and formula for Hydrocinnamoyl chloride?
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The CAS number for Hydrocinnamoyl chloride is 645-45-4, and its linear formula is C₆H₅CH₂CH₂COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Hydrocinnamoyl chloride with an assay of 98%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Hydrocinnamoyl chloride be handled safely?
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Hydrocinnamoyl chloride is a corrosive substance that causes severe skin burns and eye damage, and is toxic if inhaled. Handle with extreme caution using appropriate personal protective equipment, including chemical-resistant gloves, eye protection (goggles and face shield), and respiratory protection in a well-ventilated area or fume hood.
Is Hydrocinnamoyl chloride a controlled substance?
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Based on the provided data, Hydrocinnamoyl chloride is not indicated as a controlled substance.
How is Hydrocinnamoyl chloride packed, shipped, and exported?
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Hydrocinnamoyl chloride is packed in compliance with transport regulations for hazardous materials, including UN 3265, Class 8, Packing Group II. TSS ensures secure and compliant global export.
How can I request a sample or quote for Hydrocinnamoyl chloride?
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To request a sample or a quote for Hydrocinnamoyl chloride, please contact our sales team through the website or direct inquiry channels.
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