Hydrogen fluoride pyridine
Hydrogen fluoride pyridine (CAS: 62778-11-4), with the chemical formula C₅H₅N · (HF)ₓ, is a stable, convenient form of anhydrous hydrogen fluoride, particularly useful up to 50°C. This compound serves as a versatile reagent in organic synthesis, notably in fluorination reactions and deprotection processes. Its controlled release of HF makes it a preferred choice for various chemical transformations where anhydrous conditions are critical.
- IUPAC
- HF-Pyridine,Olah′s reagent,PPHF,Poly(pyridine fluoride),Pyridine hydrofluoride,Pyridinium poly(hydrogen fluoride),Pyridinium polybifluoride
- Synonyms
- HF-PyridineOlah's reagentPPHFPoly(pyridine fluoride)Pyridine hydrofluoridePyridinium poly(hydrogen fluoride)Pyridinium polybifluoride
Fluorination Reactions
Utilised for the synthesis of fluorinated organic compounds, including the preparation of β-fluoroamines from amino alcohols and the fluorination of acetylenes. It can also be employed in geminal fluorination of certain cyclic compounds when used in conjunction with specific oxidising agents.
Deprotection Chemistry
Serves as an effective reagent for deprotection steps in multi-step organic synthesis. Its ability to deliver fluoride ions under controlled conditions makes it suitable for cleaving specific protecting groups.
Ipso-Fluorination of Phenols
In combination with hypervalent iodine(III) reagents, it facilitates the ipso-fluorination of para-substituted phenols, yielding valuable cyclohexadienone intermediates.
| Molecular weight | 20.01 |
|---|---|
| Linear formula | C5H5N · (HF)x |
| Density | 1.1 g/mL at 20 °C(lit.) |
| Storage temperature | −20°C |
| Application | Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.1,2Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones.3 Employed with Selectfluor™ (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.4 |
| Composition | hydrogen fluoride, ~70%pyridine, ~30% |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 1790 8/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 26/27/28-35 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Hydrogen fluoride pyridine used for?
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Hydrogen fluoride pyridine is primarily used in organic synthesis for fluorination reactions, such as preparing β-fluoroamines and fluorinating acetylenes. It is also employed in the ipso-fluorination of phenols and as a deprotecting reagent.
What is the CAS number and chemical formula for Hydrogen fluoride pyridine?
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The CAS number for Hydrogen fluoride pyridine is 62778-11-4, and its chemical formula is C₅H₅N · (HF)ₓ.
What grade and purity does Tech Serve Solutions supply for Hydrogen fluoride pyridine?
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Tech Serve Solutions supplies Hydrogen fluoride pyridine with a composition of approximately 70% hydrogen fluoride and 30% pyridine. This product is supplied for laboratory and industrial research purposes and is not represented as USP, BP, EP, or other pharmacopoeial grades.
What are the safety and handling considerations for Hydrogen fluoride pyridine?
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Hydrogen fluoride pyridine is a highly corrosive and toxic substance, indicated by GHS symbols GHS05 and GHS06, with a Danger signal word. It is acutely toxic if swallowed, in contact with skin, or if inhaled (H300, H310, H330) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including full-face respirators, chemical-resistant gloves, and protective clothing, is essential. Handle only in well-ventilated areas or fume hoods.
How is Hydrogen fluoride pyridine packed, shipped, and exported by TSS?
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Tech Serve Solutions ensures that Hydrogen fluoride pyridine is appropriately packaged according to international shipping regulations for hazardous materials. We are experienced in exporting chemicals globally, adhering to all necessary compliance and documentation requirements.
How can I request a sample or quote for Hydrogen fluoride pyridine?
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To request a sample or a quote for Hydrogen fluoride pyridine, please contact our sales department through the website or by phone. Provide your specific requirements, including quantity and intended use, for a prompt response.
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