H-89 dihydrochloride hydrate
H-89 dihydrochloride hydrate (CAS 130964-39-5) is a potent and selective inhibitor of Protein Kinase A (PKA). With the molecular formula C20H20BrN3O2S · 2HCl · xH2O and a molecular weight of 519.28 g/mol (anhydrous basis), this off-white powder finds significant utility in biochemical research. It is primarily employed to investigate cellular signaling pathways and the role of PKA in various biological processes, including cell growth and differentiation.
- IUPAC
- N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride
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Protein Kinase A (PKA) Inhibition
H-89 dihydrochloride hydrate is a highly selective inhibitor of Protein Kinase A (PKA), a crucial enzyme involved in diverse cellular signalling cascades. Its use allows researchers to specifically block PKA activity and study its downstream effects on cellular processes.
Cellular Signalling Research
This compound is instrumental in dissecting complex cellular signalling pathways. By inhibiting PKA, researchers can elucidate the roles of this kinase in processes such as gene expression, metabolism, and cell cycle progression.
Neuroscience and Cell Biology Studies
H-89 is valuable in neuroscience to study the impact of PKA inhibition on neuronal function and plasticity. In cell biology, it aids in understanding cellular responses to PKA modulation, contributing to broader insights into cell behaviour and regulation.
| Molecular weight | 519.28 (anhydrous basis) |
|---|---|
| Empirical formula | C20H20BrN3O2S · 2HCl · xH2O |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | off-white |
| Solubility | H2O: ≥10 mg/mL |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is H-89 dihydrochloride hydrate used for?
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H-89 dihydrochloride hydrate is primarily used as a selective inhibitor of Protein Kinase A (PKA) in biochemical and cell biology research to study cellular signaling pathways and the biological roles of PKA.
What are the CAS number and chemical formula for H-89 dihydrochloride hydrate?
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The CAS number for the anhydrous form is 130964-39-5. The chemical formula is C20H20BrN3O2S · 2HCl · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies H-89 dihydrochloride hydrate with a purity of ≥98% by HPLC. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should H-89 dihydrochloride hydrate be handled and stored?
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Handle H-89 dihydrochloride hydrate with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Store at 2-8°C.
Does TSS export H-89 dihydrochloride hydrate?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including H-89 dihydrochloride hydrate.
How can I request a sample or quote for H-89 dihydrochloride hydrate?
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To request a sample or quote for H-89 dihydrochloride hydrate, please contact our sales team through the website or by phone.
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