H-7 dihydrochloride
H-7 dihydrochloride (CAS: 108930-17-2), with the molecular formula C14H17N3O2S · 2HCl and a molecular weight of 364.29 g/mol, is a potent protein kinase inhibitor. It selectively inhibits protein kinase C (PKC) and protein kinase A (PKA), making it a valuable tool in biochemical research for studying cellular signaling pathways. This compound is primarily used in cell biology research to modulate kinase activity and investigate downstream effects.
- IUPAC
- 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride,Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
Protein Kinase Inhibition Research
H-7 dihydrochloride is extensively used as a pharmacological tool to inhibit protein kinase A (PKA) and protein kinase C (PKC) in cellular and biochemical assays. Its selectivity allows researchers to probe the roles of these kinases in various biological processes.
Cell Signaling Studies
This compound aids in the investigation of signal transduction pathways mediated by cAMP-dependent protein kinases and calcium/phospholipid-dependent protein kinases. Researchers utilize it to understand the downstream consequences of inhibiting these critical enzymes.
Neuroscience Research
Given the involvement of PKA and PKC in neuronal function, H-7 dihydrochloride is applied in neuroscience to study processes such as neurotransmitter release, gene expression, and synaptic plasticity.
| Molecular weight | 364.29 |
|---|---|
| Empirical formula | C14H17N3O2S · 2HCl |
| Assay | ≥98% (HPLC) |
| Solubility | H2O: soluble20 mg/mL |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is H-7 dihydrochloride used for?
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H-7 dihydrochloride is primarily used in research as a selective inhibitor of protein kinase A (PKA) and protein kinase C (PKC), aiding in the study of cell signaling pathways, cell biology, and neuroscience.
What is the CAS number and formula for H-7 dihydrochloride?
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The CAS number for H-7 dihydrochloride is 108930-17-2, and its molecular formula is C14H17N3O2S · 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies H-7 dihydrochloride with a purity of ≥98% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should H-7 dihydrochloride be handled safely?
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When handling H-7 dihydrochloride, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used for respiratory protection. The compound is classified under WGK Germany 3, indicating it is hazardous.
How is H-7 dihydrochloride packed and shipped?
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H-7 dihydrochloride is typically stored at 2-8°C. Shipping and export are managed according to international regulations for chemical substances.
How can I request a sample or quote for H-7 dihydrochloride?
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To request a sample or a quote for H-7 dihydrochloride, please contact our sales team through the website or by phone.
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