Fmoc-Tyr(tBu)-OH

CAS 71989-38-3C28H29NO5Chemical Synthesis

Fmoc-Tyr(tBu)-OH (CAS 71989-38-3), a protected tyrosine derivative with the molecular formula C28H29NO5, is a key building block in peptide synthesis. Its tert-butyl protection on the phenol side chain and Fmoc group on the amine facilitate controlled peptide chain elongation. This compound is essential for creating complex peptides and peptidomimetics in pharmaceutical research and chemical biology.

IUPAC: N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine,Fmoc-O-tert-butyl-L-tyrosine
Synonyms: N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosineFmoc-O-tert-butyl-L-tyrosine

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Fmoc-Tyr(tBu)-OH (C28H29NO5) — chemical structure, CAS 71989-38-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisPeptide ChemistryTyrosine

01 /Applications

Peptide Synthesis

Fmoc-Tyr(tBu)-OH is a fundamental component in solid-phase and solution-phase peptide synthesis, enabling the incorporation of protected tyrosine residues into peptide sequences.

Drug Discovery

It serves as a crucial intermediate in the development of novel peptide-based therapeutics and peptidomimetics, aiding in the creation of compounds with enhanced stability and biological activity.

Chemical Biology Research

Researchers utilize this compound to synthesize modified peptides for studying protein-ligand interactions, enzyme mechanisms, and other biological processes.

Biochemical Reagent

This protected amino acid derivative functions as a valuable reagent in various biochemical research applications requiring precise peptide construction.

02 /Properties

Molecular weight	459.53
Empirical formula	C28H29NO5
Assay	97%
Optical activity	[α]20/D −28°, c = 1 in DMF
Melting point	153-156 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

71989-38-3

MDL number

MFCD00037129

Beilstein registry

4216652

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Fmoc-Tyr(tBu)-OH used for?

Fmoc-Tyr(tBu)-OH is primarily used as a protected amino acid building block in peptide synthesis, particularly in the development of peptide-based drugs and in chemical biology research.

What are the CAS number and formula for Fmoc-Tyr(tBu)-OH?

The CAS number for Fmoc-Tyr(tBu)-OH is 71989-38-3, and its empirical formula (Hill notation) is C28H29NO5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Fmoc-Tyr(tBu)-OH with an assay of 97%. This product is not supplied as USP, BP, EP or other pharmacopoeia grade.

What are the safety and handling precautions for Fmoc-Tyr(tBu)-OH?

Handling requires personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3.