Fmoc-Asn(Trt)-OH

CAS 132388-59-1C38H32N2O5Chemical Synthesis

Nα-Fmoc-Nγ-trityl-L-asparagine (CAS: 132388-59-1) is a protected amino acid derivative with the chemical formula C38H32N2O5 and a molecular weight of 596.67 g/mol. This compound is primarily utilised in solid-phase peptide synthesis (SPPS) to incorporate asparagine residues while protecting the side-chain amine. It serves as a critical building block in the synthesis of peptides and peptidomimetics for research and development.

IUPAC: Nα-(9-Fluorenylmethoxycarbonyl)-Nγ-trityl-L-asparagine,Nα-Fmoc-Nγ-trityl-L-asparagine
Synonyms: Nα-(9-Fluorenylmethoxycarbonyl)-Nγ-trityl-L-asparagineNα-Fmoc-Nγ-trityl-L-asparagine

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Fmoc-Asn(Trt)-OH (C38H32N2O5) — chemical structure, CAS 132388-59-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesAnalytical StandardsAnalytical/ChromatographyAsparagineChemical BiologyChemical SynthesisFM - FZPeptide Chemistry

01 /Applications

Solid-Phase Peptide Synthesis (SPPS)

Nα-Fmoc-Nγ-trityl-L-asparagine is a key reagent in SPPS, facilitating the controlled addition of asparagine to growing peptide chains. The Fmoc group allows for base-labile deprotection, while the trityl group protects the side-chain amide, preventing unwanted reactions during synthesis.

Peptide and Protein Research

This protected amino acid is essential for researchers developing novel peptides and proteins with specific biological functions or therapeutic properties. Its use ensures the accurate incorporation of asparagine, crucial for maintaining the structural integrity and activity of the target biomolecules.

Chemical Biology Studies

In chemical biology, Nα-Fmoc-Nγ-trityl-L-asparagine aids in the synthesis of modified peptides used to probe biological pathways, protein-protein interactions, and enzyme mechanisms. The side-chain protection is vital for complex synthetic strategies.

Development of Pharmaceutical Intermediates

The compound serves as a valuable intermediate in the multi-step synthesis of complex pharmaceutical agents that incorporate asparagine. Its reliable performance in synthetic routes contributes to the efficient production of active pharmaceutical ingredients (APIs).

02 /Properties

Molecular weight	596.67
Empirical formula	C38H32N2O5
Assay	≥97.0% (sum of enantiomers, HPLC)
Optical activity	[α]20/D −15.0±1°, c = 1% in methanol
Storage temperature	2-8°C
Melting point	201-204 °C(lit.)

03 /Safety & handling

Hazard statements

H413May cause long-lasting harmful effects to aquatic life

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2
Risk statements (R)	53
Safety statements (S)	61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

132388-59-1

MDL number

MFCD00077049

Beilstein registry

4343823

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Nα-Fmoc-Nγ-trityl-L-asparagine used for?

Nα-Fmoc-Nγ-trityl-L-asparagine is primarily used as a protected amino acid building block in solid-phase peptide synthesis (SPPS) and for the construction of peptides and peptidomimetics in chemical biology and pharmaceutical research.

What are the CAS number and formula for Nα-Fmoc-Nγ-trityl-L-asparagine?

The CAS number is 132388-59-1, and the chemical formula is C38H32N2O5.

What grade and purity does Tech Serve Solutions supply for Nα-Fmoc-Nγ-trityl-L-asparagine?

Tech Serve Solutions supplies Nα-Fmoc-Nγ-trityl-L-asparagine with an assay of ≥97.0% (sum of enantiomers, HPLC). This product is intended for research and technical use and is not represented as USP, BP, or EP grade.

How should Nα-Fmoc-Nγ-trityl-L-asparagine be handled and stored?

Handle Nα-Fmoc-Nγ-trityl-L-asparagine with appropriate personal protective equipment, including eyeshields, gloves, and a respirator filter (type N95 or P1). It should be stored at 2-8°C. It carries hazard statement H413 (May cause long lasting harmful effects to aquatic life).

Is this product shipped internationally?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Nα-Fmoc-Nγ-trityl-L-asparagine, and we can arrange for its export worldwide.

How can I request a quote or sample?

To request a quote or sample of Nα-Fmoc-Nγ-trityl-L-asparagine, please contact our sales team through the website or by phone, providing your specific requirements.