Ethyl N-Boc-piperidine-4-carboxylate
Ethyl N-Boc-piperidine-4-carboxylate (CAS: 142851-03-4, C13H23NO4) is a versatile heterocyclic building block for chemical synthesis. With a molecular weight of 257.33 g/mol, this piperidine derivative serves as a valuable substrate in various organic transformations, notably in palladium-catalyzed cross-coupling reactions. Its protected amine functionality and ester group offer strategic advantages for constructing complex molecular architectures in research and development settings.
- IUPAC
- Ethyl 1-(tert-Butyloxycarbonyl)isonipecotate,Ethyl 1-(tert-butoxycarbonyl)-4-piperidinecarboxylate,Piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
- Synonyms
- Ethyl 1-(tert-Butyloxycarbonyl)isonipecotateEthyl 1-(tert-butoxycarbonyl)-4-piperidinecarboxylatePiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
Palladium-Catalyzed α-Arylation
This compound is employed as a substrate in palladium-catalyzed α-arylation reactions. It reacts with heterocyclic bromides and chlorides to form novel carbon-carbon bonds, facilitating the synthesis of complex molecules.
Synthesis of Pyridylpiperidinyl Esters
It serves as a key intermediate in the preparation of 4-pyridylpiperidinyl esters. This application is crucial in medicinal chemistry for developing compounds with potential biological activity.
Heterocyclic Building Block
As a functionalised piperidine, it is a useful building block for introducing heterocyclic moieties into larger molecules. This is particularly relevant in the fields of drug discovery and materials science.
| Molecular weight | 257.33 |
|---|---|
| Empirical formula | C13H23NO4 |
| Assay | 97% |
| Boiling point | 120-135 °C/0.5 mmHg |
| Density | 1.046 g/mL at 25 °C |
| Refractive index | n20/D 1.458 |
| Application | Substrate used in a palladium-catalyzed α-arylation of esters with heterocyclic bromides and chlorides leading to, for example, 4-pyridylpiperidinyl esters.1 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl N-Boc-piperidine-4-carboxylate used for?
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Ethyl N-Boc-piperidine-4-carboxylate is used as a substrate in palladium-catalyzed α-arylation reactions and as a building block for synthesising complex molecules, including 4-pyridylpiperidinyl esters.
What is the CAS number and formula for Ethyl N-Boc-piperidine-4-carboxylate?
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The CAS number is 142851-03-4 and the empirical formula (Hill notation) is C13H23NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl N-Boc-piperidine-4-carboxylate with an assay of 97%. This product is intended for research and technical use and is not represented as USP, BP, or EP grade.
How should Ethyl N-Boc-piperidine-4-carboxylate be handled safely?
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Handling requires caution due to hazards including potential harm if swallowed (H302), skin irritation (H315), serious eye damage (H318), and respiratory irritation (H335). Use appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection.
Does Tech Serve Solutions export this chemical?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Ethyl N-Boc-piperidine-4-carboxylate.
How can I request a sample or quote?
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Please contact our sales team or use the online portal to request a sample or a quotation for Ethyl N-Boc-piperidine-4-carboxylate.
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