4-Hydroxyphenylacetic acid
4-Hydroxyphenylacetic acid (CAS: 156-38-7), with the molecular formula HOC6H4CH2CO2H and a molecular weight of 152.15, is a valuable organic compound. It serves as a key reagent in chemical synthesis, particularly for the acylation of phenols and amines. Its properties also lend themselves to applications in the development of fluorescent labels and probes.

Acylation Reagent
4-Hydroxyphenylacetic acid is employed as a reagent in the acylation of phenols and amines. This reaction is fundamental in organic synthesis for modifying functional groups and creating new molecular structures.
Fluorescent Label Development
This compound finds application in the synthesis of fluorescent labels and probes. These are critical tools in biochemical research and diagnostics for detecting and visualizing biological molecules.
Organic Building Block
As a versatile organic building block, 4-Hydroxyphenylacetic acid can be incorporated into more complex molecular architectures for various research and development purposes.
| Molecular weight | 152.15 |
|---|---|
| Linear formula | HOC6H4CH2CO2H |
| Assay | 98% |
| Application | Reagent used in the acylation of phenols1 and amines.2 |
| Melting point | 148-151 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxyphenylacetic acid used for?
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4-Hydroxyphenylacetic acid is primarily used as a reagent for the acylation of phenols and amines in organic synthesis. It also serves as a building block for developing fluorescent labels and probes.
What are the CAS number and molecular formula for 4-Hydroxyphenylacetic acid?
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The CAS number for 4-Hydroxyphenylacetic acid is 156-38-7, and its molecular formula is HOC6H4CH2CO2H.
What grade and purity does Tech Serve Solutions supply for 4-Hydroxyphenylacetic acid?
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Tech Serve Solutions supplies 4-Hydroxyphenylacetic acid with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling 4-Hydroxyphenylacetic acid?
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4-Hydroxyphenylacetic acid is classified as a Warning substance with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (N95 type), should be worn. Ensure good ventilation.
How is 4-Hydroxyphenylacetic acid packed, shipped, and exported?
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Tech Serve Solutions ensures careful packaging for all our chemical products. We offer global export services, adhering to all relevant shipping regulations for fine chemicals.
How can I request a sample or quote for 4-Hydroxyphenylacetic acid?
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To request a sample or obtain a quotation for 4-Hydroxyphenylacetic acid, please contact our sales department through the website or by phone.
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