4-Hydroxyphenylboronic acid pinacol ester
4-Hydroxyphenylboronic acid pinacol ester (CAS: 269409-70-3, C12H17BO3) is a key organoboronate compound with a molecular weight of 220.07 g/mol. It functions as a valuable building block in organic synthesis, particularly recognised for its utility in Suzuki-Miyaura cross-coupling reactions. This ester derivative offers enhanced stability and handling compared to its corresponding boronic acid, making it a preferred reagent in various synthetic chemistry applications within research and development.
- IUPAC
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol,4-Hydroxyphenylboronic acid pinacol cyclic ester
- Synonyms
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol4-Hydroxyphenylboronic acid pinacol cyclic ester
Suzuki-Miyaura Coupling
This compound is widely employed as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions. It enables the formation of carbon-carbon bonds, facilitating the synthesis of complex biaryl structures critical in pharmaceutical and materials science.
Organic Synthesis Intermediate
As an aryl boronate ester, it serves as a versatile intermediate for introducing the 4-hydroxyphenyl moiety into organic molecules. This functionality is important for modifying drug candidates or creating novel organic materials.
Reagent for Complex Molecule Synthesis
Its reliable reactivity and stability make it suitable for multi-step syntheses of advanced organic compounds. Researchers utilise this ester in the construction of diverse molecular architectures.
| Molecular weight | 220.07 |
|---|---|
| Empirical formula | C12H17BO3 |
| Assay | 97% |
| Application | Widely used in Suzuki coupling chemistry.1,2 |
| Melting point | 113-117 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxyphenylboronic acid pinacol ester used for?
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4-Hydroxyphenylboronic acid pinacol ester is primarily used in Suzuki-Miyaura coupling reactions for carbon-carbon bond formation and as a versatile intermediate in complex organic synthesis.
What are the CAS number and chemical formula for 4-Hydroxyphenylboronic acid pinacol ester?
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The CAS number is 269409-70-3 and the chemical formula is C12H17BO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Hydroxyphenylboronic acid pinacol ester with a minimum assay of 97%. This product is suitable for research and chemical synthesis and is not represented as USP, BP, or EP grade.
How should 4-Hydroxyphenylboronic acid pinacol ester be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid inhalation of dust and ensure adequate ventilation. It is classified as a Warning with hazards H315, H319, and H335, indicating skin, eye, and respiratory irritation.
Does Tech Serve Solutions export this chemical?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-Hydroxyphenylboronic acid pinacol ester.
How can I request a quote or sample?
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To request a quote or sample of 4-Hydroxyphenylboronic acid pinacol ester, please use the 'Request a Quote' or 'Request Sample' buttons available on the product page, or contact our sales team directly.
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