4-Hydroxypiperidine hydrochloride
4-Hydroxypiperidine hydrochloride (CAS 5382-17-2), with the molecular formula C5H11NO · HCl and a molecular weight of 137.61 g/mol, is a vital heterocyclic building block. It serves as a key reactant in the synthesis of radiolabeled compounds for medical imaging and in the development of modulators for specific brain receptors. This compound is essential for advanced chemical synthesis and research applications.
- IUPAC
- 4-Piperidinol hydrochloride
- Synonyms
- 4-Piperidinol hydrochloride

Synthesis of PET Tracers
Utilised as a reactant in the synthesis of 14C-labeled compounds, such as E4010, for use as PET (Positron Emission Tomography) tracers. These tracers enable the imaging of brain acetylcholinesterase activity.
Allosteric Modulator Development
Serves as a reactant in the creation of allosteric modulators targeting the metabotropic glutamate receptor subtype 5. This is crucial for research into neurological and psychiatric disorders.
Chemical Synthesis Intermediate
A versatile intermediate within the C5 to C7 range for general chemical synthesis. Its structure makes it valuable for constructing more complex heterocyclic molecules.
| Molecular weight | 137.61 |
|---|---|
| Empirical formula | C5H11NO · HCl |
| Assay | 98% |
| Application | Reactant for synthesis of: 14C-labeled E40101 PET tracer for imaging brain acetylcholinesterase2Reactant for allosteric modulators of metabotropic glutamate receptor subtype 53 |
| Melting point | 155-157 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxypiperidine hydrochloride used for?
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4-Hydroxypiperidine hydrochloride is used as a reactant in the synthesis of 14C-labeled compounds for PET imaging tracers (e.g., brain acetylcholinesterase imaging) and in the development of allosteric modulators for metabotropic glutamate receptor subtype 5.
What is the CAS number and formula for 4-Hydroxypiperidine hydrochloride?
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The CAS number is 5382-17-2 and the empirical formula is C5H11NO · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Hydroxypiperidine hydrochloride with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product data.
How should 4-Hydroxypiperidine hydrochloride be handled?
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This compound is a Warning material that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. Ensure adequate ventilation.
Is 4-Hydroxypiperidine hydrochloride a controlled substance?
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The provided data does not indicate that 4-Hydroxypiperidine hydrochloride (CAS 5382-17-2) is a controlled substance.
How is 4-Hydroxypiperidine hydrochloride packed, shipped, or exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, packages and ships chemicals according to international regulations to ensure safe and compliant delivery worldwide.
How can I request a sample or quote for 4-Hydroxypiperidine hydrochloride?
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To request a sample or quote, please contact our sales team via the website or direct inquiry, providing the product name and CAS number (5382-17-2).
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