4-Hydroxyphenylboronic acid
Tech Serve Solutions proudly supplies 4-Hydroxyphenylboronic acid (CAS: 71597-85-8), a white to off-white solid with the formula HOC6H4B(OH)2 and a molecular weight of 137.93 g/mol. This versatile aryl boronic acid is a key reagent in organic synthesis, notably employed in Suzuki-Miyaura and Stille coupling reactions. It also finds application in palladium-catalyzed transformations and the preparation of various biologically active compounds.
- IUPAC
- (p-Hydroxyphenyl)boronic acid,4-Hydroxybenzeneboronic acid,p-hydroxy-benzeneboronic acid
- Synonyms
- (p-Hydroxyphenyl)boronic acid4-Hydroxybenzeneboronic acidp-hydroxy-benzeneboronic acid
Suzuki-Miyaura and Stille Coupling
4-Hydroxyphenylboronic acid is a valuable substrate for Suzuki-Miyaura and Stille coupling reactions, enabling the introduction of diverse aryl and alkyl groups into target molecules.
Palladium-Catalyzed Reactions
It serves as a reagent in palladium-catalyzed aminocarbonylation and other cross-coupling reactions, facilitating the synthesis of complex organic structures.
Preparation of Biological Agents
This compound is instrumental in the synthesis of potential anti-cancer therapeutics, including PDK1 inhibitors and estrone-derived cyclopamine analogs, as well as enzyme inhibitors for bacterial infections.
Polymer Synthesis
It is utilised in the preparation of rod-like dendronized polymers via macromonomer approaches using living ring-opening metathesis polymerisation (ROMP).
| Molecular weight | 137.93 |
|---|---|
| Linear formula | HOC6H4B(OH)2 |
| Assay | ≥95.0% |
| Application | Reagent used for• Suzuki-Miyaura coupling and Stille coupling and potential for introducing different alkyl groups1 • Palladium-catalyzed aminocarbonylation and cross-coupling reactions2 • Bio-supported palladium nanoparticles as phosphine-free catalyst for Suzuki reaction in water3 • Cu2O-catalyzed aerobic oxidative cross-coupling of tetrazoles4 Reagent used in Preparation of• PDK1 inhibitory activity (cancer cell growth, survival, and tumorigenesis inhibitor)5 • Rod-like dendronized polymers contg. G4 and G5 ester dendrons via macromonomer approach by living ROMP6 • Estrone-derived cyclopamine analogs as Sonic Hedgehog signaling inhibitors for anti-cancer chemotherapeutics7 • Enzymatic inhibitors for the treatment of gram-negative bacterial infections8 |
| Melting point | >230 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Hydroxyphenylboronic acid used for?
+
4-Hydroxyphenylboronic acid is primarily used as a reagent in organic synthesis, particularly for Suzuki-Miyaura coupling, Stille coupling, palladium-catalyzed aminocarbonylation, and in the preparation of various biologically active compounds and polymers.
What is the CAS number and molecular formula?
+
The CAS number for 4-Hydroxyphenylboronic acid is 71597-85-8, and its molecular formula is HOC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 4-Hydroxyphenylboronic acid with an assay of ≥95.0%. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
How should 4-Hydroxyphenylboronic acid be handled safely?
+
4-Hydroxyphenylboronic acid is a Warning substance (GHS07) and is classified with hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). It is recommended to wear a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. In case of contact, rinse thoroughly with water.
Is this chemical suitable for export?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-Hydroxyphenylboronic acid.
How can I request a sample or quote?
+
To request a sample or obtain a quotation for 4-Hydroxyphenylboronic acid, please contact our sales team through the website or via direct enquiry.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis