Ethyl N-Boc-4-methylpiperidine-4-carboxylate
Ethyl N-Boc-4-methylpiperidine-4-carboxylate (CAS: 189442-87-3; Formula: C14H25NO4; MW: 271.35) is a heterocyclic building block utilised in chemical synthesis. This compound, featuring a piperidine core with Boc protection and an ethyl carboxylate group, serves as a crucial intermediate. Its primary application lies in the synthesis of complex organic molecules, particularly in the development of pharmaceutical agents where the piperidine moiety is a common structural motif.
- IUPAC
- 1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxylic acid ethyl ester,4-Methyl-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester
- Synonyms
- 1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxylic acid ethyl ester4-Methyl-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester
Pharmaceutical Intermediate Synthesis
This compound is employed as a key building block in the synthesis of advanced pharmaceutical intermediates. Its structure is particularly relevant for constructing piperazine-based CCR5 antagonists by enabling the replacement of its ester function with an amino group.
Organic Synthesis Reagent
As a functionalised piperidine derivative, it is a valuable reagent in general organic synthesis. It allows for the introduction of a protected 4-methylpiperidine-4-carboxylate moiety into larger molecular frameworks.
Medicinal Chemistry Research
The compound is utilised in medicinal chemistry research for the exploration of new therapeutic agents. Its specific structure facilitates the development of drug candidates targeting various biological pathways.
| Molecular weight | 271.35 |
|---|---|
| Empirical formula | C14H25NO4 |
| Assay | 97% |
| Density | 1.0134 g/mL at 25 °C |
| Refractive index | n20/D 1.4554 |
| Application | Replacement of the ester function with an amino group provides a key building block for piperazine-based CCR5 antagonists.2 |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-37/38-41 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl N-Boc-4-methylpiperidine-4-carboxylate used for?
+
Ethyl N-Boc-4-methylpiperidine-4-carboxylate is primarily used as a building block in chemical synthesis, notably as an intermediate in the preparation of pharmaceutical agents such as piperazine-based CCR5 antagonists.
What are the CAS number and molecular formula?
+
The CAS number for Ethyl N-Boc-4-methylpiperidine-4-carboxylate is 189442-87-3, and its molecular formula is C14H25NO4.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Ethyl N-Boc-4-methylpiperidine-4-carboxylate with a minimum purity of 97%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should Ethyl N-Boc-4-methylpiperidine-4-carboxylate be handled safely?
+
Handling requires significant caution due to its hazardous properties. It is corrosive and toxic, indicated by GHS05 and GHS06 symbols, with a 'Danger' signal word. Hazards include toxicity if swallowed (H301), skin irritation (H315), serious eye damage (H318), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (e.g., full-face respirator or ABEK filter), is essential. Work should be conducted in a well-ventilated area.
Is this product a controlled substance?
+
Based on the provided data, there is no indication that Ethyl N-Boc-4-methylpiperidine-4-carboxylate is a controlled substance.
How is this chemical packed, shipped, and exported?
+
This chemical is shipped under UN 2810, hazard class 6.1, packing group III. TSS offers global export services, adhering to all relevant shipping and customs regulations for hazardous materials.
How can I request a sample or quote?
+
To request a sample or a quote for Ethyl N-Boc-4-methylpiperidine-4-carboxylate, please contact our sales department via the website or direct email, providing your specific requirements and delivery details.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis