Ethyl N-Boc-4-allylpiperidine-4-carboxylate
Ethyl N-Boc-4-allylpiperidine-4-carboxylate (CAS: 146603-99-8, C16H27NO4) is a versatile chemical building block with a molecular weight of 297.39 g/mol. This protected piperidine derivative is utilised in complex organic synthesis, notably as a reactant in the preparation of specific pharmaceutical compounds. Its chemical structure lends itself to further derivatisation, making it a valuable intermediate for researchers and synthetic chemists.
- IUPAC
- 1-(1,1-Dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate,Ethyl 4-allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylate
- Synonyms
- 1-(1,1-Dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylateEthyl 4-allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylate
Synthesis of T-type Calcium Channel Antagonists
This compound serves as a key reactant in the synthesis of T-type calcium channel antagonists. These are classes of drugs investigated for their potential therapeutic applications in various neurological conditions.
Heterocyclic Building Block
As a functionalised piperidine, it acts as a valuable heterocyclic building block in medicinal chemistry and drug discovery programmes. Its structure allows for diverse synthetic modifications.
Organic Synthesis Intermediate
It is employed as an intermediate in multi-step organic synthesis pathways. The tert-butoxycarbonyl (Boc) protecting group offers selective reactivity and facile removal when required.
| Molecular weight | 297.39 |
|---|---|
| Empirical formula | C16H27NO4 |
| Assay | 90% |
| Boiling point | 130-135 °C/1.5 mmHg |
| Density | 1.020 g/mL at 25 °C |
| Refractive index | n20/D 1.4676 |
| Application | Reactant for synthesis of T-type calcium channel antagonists1 |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl N-Boc-4-allylpiperidine-4-carboxylate used for?
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Ethyl N-Boc-4-allylpiperidine-4-carboxylate is primarily used as a reactant in the synthesis of T-type calcium channel antagonists and as a versatile building block in organic synthesis.
What is the CAS number and chemical formula?
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The CAS number is 146603-99-8, and the empirical formula (Hill notation) is C16H27NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with a minimum assay of 90%. It is suitable for research and chemical synthesis purposes. We do not represent it as USP, BP, or EP grade.
What are the safety and handling recommendations?
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This compound is classified as harmful if swallowed (H302). It requires appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Handle in a well-ventilated area.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and reagents, adhering to all necessary regulations for safe transport and international shipping.
How can I request a sample or quote?
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To request a sample or a quote for Ethyl N-Boc-4-allylpiperidine-4-carboxylate, please contact our sales department through the TSS website or directly via email/phone.
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