DMT-2′O-Methyl-rA(bz) Phosphoramidite
DMT-2′O-Methyl-rA(bz) Phosphoramidite (CAS: 110782-31-5) is a high-purity chemical compound with the formula C48H54N7O8P and a molecular weight of 887.96. This phosphoramidite derivative is essential for the chemical synthesis of modified RNA oligonucleotides. Supplied by Tech Serve Solutions, it is a critical reagent for researchers and manufacturers involved in oligonucleotide synthesis, particularly for applications requiring 2'-O-methylated adenosine residues. Its precise structure and purity ensure reliable incorporation into synthetic nucleic acids.
- IUPAC
- DMT-2′-O-Me-rA(bz) amidite
- Synonyms
- DMT-2′-O-Me-rA(bz) amidite
Oligonucleotide Synthesis
DMT-2′O-Methyl-rA(bz) Phosphoramidite is a key building block for the synthesis of modified RNA oligonucleotides. It is specifically designed for incorporation into nucleic acid chains using automated synthesizers, enabling the creation of custom RNA sequences.
Research and Development
This phosphoramidite is utilized in academic and industrial research settings for the development of novel nucleic acid-based therapeutics, diagnostics, and tools. Its 2'-O-methylation provides enhanced stability and modified binding properties to the resulting oligonucleotides.
Chemical Synthesis Reagent
As a specialized reagent, it plays a crucial role in complex organic synthesis workflows, contributing to the precise construction of oligonucleotides with specific chemical modifications.
| Molecular weight | 887.96 |
|---|---|
| Empirical formula | C48H54N7O8P |
| Assay | ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)conforms (1H-NMR)conforms (LC/MS) |
| Form | powder |
| Colour | white to off-white |
| Storage temperature | 2-8°C |
| Impurities tested | ≤0.3 wt. % water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3 wt. % residual Solvent content |
| Biological source | from non-animal source≥99.0% (reversed phase HPLC)BSE/TSE Risk (No Risk)conforms (1H-NMR) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Product Line | Proligo Reagentsconforms (LC/MS) |
|---|---|
| Packaging | pkg of 1 × 0.5 g (A211131-01)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)pkg of 1 × 1 g (A211161-01)≤0.5% single Impurity (reversed phase HPLC) |
| Applications | oligo synthesis: suitable≤3 wt. % residual Solvent content |
| λ | conforms (UV/VIS Identity) |
| Compatibility | configured for ABI |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DMT-2′O-Methyl-rA(bz) Phosphoramidite used for?
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DMT-2′O-Methyl-rA(bz) Phosphoramidite is primarily used as a building block in the chemical synthesis of modified RNA oligonucleotides, particularly for research and development in nucleic acid chemistry and therapeutic applications.
What are the CAS number and formula for this product?
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The CAS number for DMT-2′O-Methyl-rA(bz) Phosphoramidite is 110782-31-5, and its empirical formula is C48H54N7O8P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies DMT-2′O-Methyl-rA(bz) Phosphoramidite with an assay of ≥99% (31P-NMR) and ≥99.0% (reversed phase HPLC). This product is intended for research purposes and is not supplied as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling recommendations for DMT-2′O-Methyl-rA(bz) Phosphoramidite?
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This compound requires careful handling. Recommended personal protective equipment includes eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It carries a WGK Germany rating of 3, indicating a high hazard level.
How is DMT-2′O-Methyl-rA(bz) Phosphoramidite packaged and exported?
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DMT-2′O-Methyl-rA(bz) Phosphoramidite is available in powder form and is typically packaged in quantities such as 0.5 g or 1 g. Tech Serve Solutions is a global supplier and exporter of fine chemicals.
How can I request a sample or quote for DMT-2′O-Methyl-rA(bz) Phosphoramidite?
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To request a sample or a quote for DMT-2′O-Methyl-rA(bz) Phosphoramidite, please contact our sales department through the Tech Serve Solutions website or by phone.
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