DMT-2′Fluoro-dC(ac) Phosphoramidite
DMT-2′Fluoro-dC(ac) Phosphoramidite (CAS: 159414-99-0) is a crucial phosphoramidite building block for oligonucleotide synthesis. With the empirical formula C41H49FN5O8P and a molecular weight of 789.83 g/mol, this compound is vital for introducing modified nucleosides into DNA and RNA sequences. It is primarily used in chemical synthesis and research applications requiring precise genetic material modification.
- IUPAC
- DMT-2′-F-dC(ac) amidite
Oligonucleotide Synthesis
This phosphoramidite is a key reagent for the automated synthesis of DNA and RNA strands. It enables the incorporation of a 2'-fluoro-deoxycytidine analogue, allowing for the creation of modified oligonucleotides with altered biochemical properties.
Medicinal Chemistry Research
Used in the development of novel therapeutic oligonucleotides, such as antisense drugs and siRNA. The 2'-fluoro modification can enhance nuclease resistance and binding affinity of the resulting nucleic acid molecules.
Biochemical and Genetic Studies
Facilitates the study of nucleic acid structure-function relationships. Incorporating this modified nucleoside can probe interactions with proteins or help understand enzymatic processes involving DNA and RNA.
| Molecular weight | 789.83 |
|---|---|
| Empirical formula | C41H49FN5O8P |
| Assay | ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)conforms (1H-NMR)conforms (LC/MS) |
| Colour | solid white to light yellow Appearanceclear Appearance of Solutionsolution (c=0.2M in ACN) |
| Storage temperature | −20°C |
| Impurities tested | ≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3% residual Solvent content |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Packaging | pkg of 1 × 100 g C213211-01pkg of 1 × 500 g C213251-01 |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DMT-2′Fluoro-dC(ac) Phosphoramidite used for?
+
DMT-2′Fluoro-dC(ac) Phosphoramidite is used as a building block in the chemical synthesis of modified oligonucleotides, particularly for research in medicinal chemistry and molecular biology.
What is the CAS number and formula for DMT-2′Fluoro-dC(ac) Phosphoramidite?
+
The CAS number is 159414-99-0, and the empirical formula is C41H49FN5O8P.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies DMT-2′Fluoro-dC(ac) Phosphoramidite with an assay of ≥99% (31P-NMR) and ≥99.0% (reversed phase HPLC). It is supplied as a technical/research grade material and is not represented as USP, BP, or EP grade.
How should DMT-2′Fluoro-dC(ac) Phosphoramidite be handled?
+
Handle DMT-2′Fluoro-dC(ac) Phosphoramidite with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or P1 (EN143) respirator filter may be necessary. Store at -20°C.
Is DMT-2′Fluoro-dC(ac) Phosphoramidite subject to any special controls?
+
Based on the provided data, there is no indication that DMT-2′Fluoro-dC(ac) Phosphoramidite is a scheduled or controlled substance. However, users should always comply with local regulations.
How is this chemical packaged and exported?
+
This chemical is available in packages of 100 g and 500 g. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a quote or sample?
+
To request a quote or sample of DMT-2′Fluoro-dC(ac) Phosphoramidite, please contact our sales team through the website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis