DMT-2′Fluoro-dU Phosphoramidite
DMT-2′Fluoro-dU Phosphoramidite (CAS: 146954-75-8; C39H46FN4O8P) is a high-purity chemical reagent with a molecular weight of 748.78. It is primarily utilised in chemical synthesis for the creation of modified oligonucleotides. This phosphoramidite is specifically configured for use in ABI synthesizers, enabling the incorporation of 2'-fluoro-deoxyuridine into DNA sequences. Its applications extend to research in nucleic acid chemistry and the development of therapeutic oligonucleotides.
- IUPAC
- DMT-2′-Fluoro-dU amidite
- Synonyms
- DMT-2'-Fluoro-dU amidite
Oligonucleotide Synthesis
DMT-2′Fluoro-dU Phosphoramidite is a key building block for the automated synthesis of DNA sequences. It enables the incorporation of modified nucleosides, specifically 2'-fluorinated deoxyuridine, into oligonucleotides.
Nucleic Acid Research
This compound is vital for researchers investigating the properties and functions of modified nucleic acids. The 2'-fluoro modification can confer increased stability and alter binding characteristics of DNA.
Therapeutic Oligonucleotide Development
The incorporation of 2'-fluorinated bases is a strategy employed in the development of antisense oligonucleotides and other nucleic acid-based therapeutics due to enhanced pharmacokinetic properties.
ABI Synthesizer Compatibility
This phosphoramidite is configured for seamless integration with ABI 3900 and ABI 39X DNA synthesizers, ensuring reliable and efficient oligonucleotide production.
| Molecular weight | 748.78 |
|---|---|
| Empirical formula | C39H46FN4O8P |
| Assay | ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)conforms (1H-NMR)conforms (LC/MS) |
| Colour | solid white to light yellow Appearance |
| Storage temperature | −20°C |
| Impurities tested | ≤0.3% water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3% residual Solvent content |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Packaging | pkg of 1 × 0.25 g U211231-01 |
|---|---|
| Compatibility | configured for ABI |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DMT-2′Fluoro-dU Phosphoramidite used for?
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DMT-2′Fluoro-dU Phosphoramidite is used in chemical synthesis for the incorporation of 2'-fluoro-deoxyuridine into DNA during automated oligonucleotide synthesis, particularly for research and therapeutic development.
What is the CAS number and formula for DMT-2′Fluoro-dU Phosphoramidite?
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The CAS number is 146954-75-8 and the empirical formula is C39H46FN4O8P.
What grade and purity does Tech Serve Solutions supply for DMT-2′Fluoro-dU Phosphoramidite?
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Tech Serve Solutions supplies DMT-2′Fluoro-dU Phosphoramidite with an assay of ≥99% (31P-NMR) and ≥99.0% (reversed phase HPLC). This product is supplied for research purposes and TSS does not represent it as USP, BP, EP, or other pharmacopoeial grade.
What are the safety and handling requirements for DMT-2′Fluoro-dU Phosphoramidite?
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Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The substance is classified with WGK Germany 3.
How is DMT-2′Fluoro-dU Phosphoramidite packaged and shipped?
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This product is typically supplied in a pkg of 0.25 g. It is stored at -20°C. TSS exports fine chemicals globally, adhering to all necessary shipping regulations.
How can I request a quote or sample for DMT-2′Fluoro-dU Phosphoramidite?
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To request a quote or sample, please contact our sales team via the website or direct email, providing your details and the product's CAS number (146954-75-8).
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