DMT-2′O-TBDMS-rG(ib) Phosphoramidite
DMT-2′O-TBDMS-rG(ib) Phosphoramidite (CAS: 147201-04-5) is a critical building block for RNA synthesis, bearing the empirical formula C50H68N7O9PSi and a molecular weight of 970.18 g/mol. This high-purity phosphoramidite, derived from a non-animal source, is specifically configured for automated oligonucleotide synthesizers like the MerMade. It is essential for the controlled, stepwise incorporation of modified guanosine residues into synthetic RNA strands for research and development.
- Synonyms
- DMT-2'-O-TBDMS-rG(ib)- phosphoramidite2'-O-tert-Butyldimethylsilyladenosine 3'-[bis(2-cyanoethyl)]phosphoramidite, N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)guanosine
Oligonucleotide Synthesis
This reagent is specifically designed for the automated synthesis of RNA oligonucleotides. Its phosphoramidite chemistry enables the efficient and precise addition of 2'-O-TBDMS protected guanosine units to growing RNA chains.
Chemical Synthesis Reagent
As a specialized phosphoramidite, it serves as a key intermediate in complex chemical synthesis pathways, particularly those involving modified nucleic acids. Its purity ensures reliable outcomes in multi-step synthetic processes.
Research and Development
Used extensively in molecular biology and biotechnology research, this compound facilitates the creation of custom RNA molecules for applications such as RNA interference (RNAi), mRNA therapeutics, and diagnostic probes.
| Molecular weight | 970.18 |
|---|---|
| Empirical formula | C50H68N7O9PSi |
| Assay | ≥99% (31P-NMR)≥99.0% (reversed phase HPLC)conforms (1H-NMR)conforms (LC/MS) |
| Form | powderpkg of 1 × 1 g (G211043-01) |
| Colour | white to off-white |
| Storage temperature | −20°C |
| Impurities tested | ≤0.3 wt. % water content (Karl Fischer)≤0.5% P(III) Impurities 100-169ppm (31P-NMR)≤0.5% single Impurity (reversed phase HPLC)≤3 wt. % residual Solvent content |
| Biological source | from non-animal source |
| Product Line | Proligo Reagents≥99.0% (reversed phase HPLC) |
|---|---|
| Packaging | pkg of 1 × 0.5 g (A211041-01) |
| Applications | oligo synthesis: suitable≤0.5% P(III) Impurities 100-169ppm (31P-NMR) |
| λ | conforms (UV/VIS Identity) |
| Compatibility | configured for MerMade |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DMT-2′O-TBDMS-rG(ib) Phosphoramidite used for?
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DMT-2′O-TBDMS-rG(ib) Phosphoramidite is primarily used in the automated synthesis of RNA oligonucleotides. It serves as a building block for incorporating modified guanosine residues into synthetic RNA strands.
What are the CAS number and formula for DMT-2′O-TBDMS-rG(ib) Phosphoramidite?
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The CAS number is 147201-04-5, and the empirical formula is C50H68N7O9PSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies DMT-2′O-TBDMS-rG(ib) Phosphoramidite with a purity of ≥99% by 31P-NMR and ≥99.0% by reversed-phase HPLC. It is supplied as a technical/research grade material and is not represented as USP, BP, or EP.
How is DMT-2′O-TBDMS-rG(ib) Phosphoramidite packaged and shipped?
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This product is available in packaging sizes such as 0.5 g and 1 g, supplied as a white to off-white powder. It requires storage at -20°C. TSS exports this chemical globally.
What safety precautions should be taken when handling this compound?
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While specific GHS hazard data is not detailed here, phosphoramidites are typically handled with care in a well-ventilated area, using appropriate personal protective equipment (gloves, eye protection) to avoid contact and inhalation. Consult the Safety Data Sheet (SDS) for detailed hazard information.
How can I request a sample or quote for this product?
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To request a sample or a quote for DMT-2′O-TBDMS-rG(ib) Phosphoramidite, please contact our sales team through the TSS website or by phone.
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