Ethyl (4-chlorobenzoyl)acetate
Ethyl (4-chlorobenzoyl)acetate (CAS: 2881-63-2) is a key organic building block and ester derivative. With a molecular weight of 226.66 g/mol, it serves as a versatile reactant in various chemical syntheses. Its applications span the preparation of antiplasmodial agents, potential antitumor compounds via SIRT inhibition, and mineralocorticoid receptor antagonists, demonstrating its utility in pharmaceutical research and development.
- IUPAC
- 3-(4-Chlorophenyl)-3-oxopropanoic acid ethyl ester,Ethyl 3-(4-chlorophenyl)-3-oxopropanoate,NSC 406743
- Synonyms
- 3-(4-Chlorophenyl)-3-oxopropanoic acid ethyl esterEthyl 3-(4-chlorophenyl)-3-oxopropanoateNSC 406743
Synthesis of Pharmaceutical Agents
This compound is employed in the synthesis of antiplasmodial agents and potential antitumor agents, specifically those acting as SIRT 1/2 inhibitors. It also finds use in preparing mineralocorticoid receptor antagonists.
Chemical Reactions and Transformations
Ethyl (4-chlorobenzoyl)acetate participates in tandem condensation-cyclization reactions and stereoselective ketonization-olefination of indoles. It is also a reactant in intramolecular Michael addition reactions.
Organic Synthesis Intermediate
As a functionalised ester and carbonyl compound, it serves as a valuable intermediate in broader organic synthesis, particularly for constructing complex molecular architectures.
| Molecular weight | 226.66 |
|---|---|
| Linear formula | ClC6H4COCH2CO2C2H5 |
| Boiling point | 268-269 °C(lit.) |
| Density | 1.218 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5500(lit.) |
| Application | Reactant involved in:• Tandem condensation-cyclization reactions1• Stereoselective ketonization-olefination of indoles2• Synthesis of antiplasmodial agents3• SIRT 1/2 inhibitor preparation for use as antitumor agents4• Synthesis of mineralocorticoid receptor antagonists5• Intramolecular Michael addition reactions6 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (4-chlorobenzoyl)acetate used for?
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Ethyl (4-chlorobenzoyl)acetate is used as a reactant in various chemical syntheses, including the preparation of antiplasmodial agents, antitumor agents, and mineralocorticoid receptor antagonists. It is also involved in tandem condensation-cyclization reactions and stereoselective ketonization-olefination of indoles.
What is the CAS number and chemical formula for Ethyl (4-chlorobenzoyl)acetate?
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The CAS number is 2881-63-2 and the linear formula is ClC6H4COCH2CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical as a research or technical grade material. We do not represent it as meeting USP, BP, or EP pharmacopoeia standards unless explicitly stated otherwise in the product specifications.
How should Ethyl (4-chlorobenzoyl)acetate be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the safety data sheet for comprehensive handling information.
Is Ethyl (4-chlorobenzoyl)acetate a controlled substance?
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The provided data does not indicate that Ethyl (4-chlorobenzoyl)acetate is a controlled substance.
How is Ethyl (4-chlorobenzoyl)acetate supplied and exported?
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As a global supplier, Tech Serve Solutions exports chemicals worldwide. Packaging and shipping adhere to relevant international regulations for chemical transport.
How can I request a sample or quote for Ethyl (4-chlorobenzoyl)acetate?
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To request a sample or a quotation, please contact our sales team through the website or by phone, providing the product name and CAS number.
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