2,2,5,7,8-Pentamethyl-chromane-6-sulfonyl chloride
2,2,5,7,8-Pentamethyl-chromane-6-sulfonyl chloride (CAS: 112160-39-1) is a key organic compound with the molecular formula C14H19ClO3S and a molecular weight of 302.82 g/mol. It serves as a versatile reagent in chemical synthesis, particularly in the field of peptide chemistry for guanidine protection and guanidinylation. Its specific structural features make it valuable for complex organic transformations.
- IUPAC
- 3,4-Dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl chloride,Pmc-Cl
- Synonyms
- 7,8-Pentamethyl-chromane-6-sulfonyl chloridePmc-Cl
Guanidine Protection
This sulfonyl chloride derivative is effectively employed as a protecting group for guanidines in peptide synthesis. It facilitates selective modification and coupling reactions by temporarily masking the reactive guanidine functionality.
Guanidinylation Reagent
It acts as a guanidinylating agent, enabling the introduction of a guanidine group into organic molecules. This is crucial for the synthesis of various biologically relevant compounds and modified amino acids.
Peptide Chemistry
Within peptide chemistry, this compound aids in the construction of complex peptide chains and modified peptides. Its application ensures precise control over the guanidine side chains of amino acids like arginine.
Chemical Synthesis
As a functionalized sulfonyl chloride, it finds utility in broader organic synthesis for creating novel molecular architectures and intermediates. It can be used in various coupling and derivatization reactions.
| Molecular weight | 302.82 |
|---|---|
| Empirical formula | C14H19ClO3S |
| Assay | ≥97.0% (HPLC) |
| Storage temperature | −20°C |
| Melting point | 77-82 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,5,7,8-Pentamethyl-chromane-6-sulfonyl chloride used for?
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This compound is primarily used as a reagent in chemical synthesis, specifically for the protection and guanidinylation of guanidines in peptide chemistry.
What are the CAS number and molecular formula?
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The CAS number is 112160-39-1, and the molecular formula is C14H19ClO3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with a minimum purity of 97.0% as determined by HPLC. We do not represent this product as USP, BP, or EP grade.
How should 2,2,5,7,8-Pentamethyl-chromane-6-sulfonyl chloride be handled?
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This compound is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). It requires appropriate personal protective equipment, including eyeshields, face shields, and chemical-resistant gloves. Handling should be done in a well-ventilated area or under a fume hood. Consult the Safety Data Sheet for detailed information.
Is this chemical available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2,2,5,7,8-Pentamethyl-chromane-6-sulfonyl chloride.
How can I request a sample or quote?
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To request a sample or a quote for 2,2,5,7,8-Pentamethyl-chromane-6-sulfonyl chloride, please contact our sales team through the website or by phone.
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