Diethyl cyanomethylphosphonate
Diethyl cyanomethylphosphonate (CAS 2537-48-6) is a chemical reagent with the linear formula NCCH2PO(OC2H5)2 and a molecular weight of 177.14 g/mol. It is characterised by its utility in synthetic organic chemistry, particularly as a key component in C-C bond formation reactions. This compound serves as a valuable building block for creating more complex organic molecules.
- IUPAC
- (Diethylphosphono)acetonitrile,Cyanomethylphosphonic acid diethyl ester
- Synonyms
- (Diethylphosphono)acetonitrileCyanomethylphosphonic acid diethyl ester
Horner-Wadsworth-Emmons Reagent
Diethyl cyanomethylphosphonate is a widely used reagent in the Horner-Wadsworth-Emmons reaction for the synthesis of alpha,beta-unsaturated nitriles. This olefination method is essential for introducing carbon-carbon double bonds.
C-C Bond Formation
This phosphonate ester is instrumental in forming new carbon-carbon bonds. Its reactivity allows for the construction of various organic frameworks in multi-step syntheses.
Chemical Synthesis
As a versatile synthetic reagent, it finds application in diverse chemical synthesis pathways. It is employed to introduce the cyanomethyl group or to participate in olefination reactions.
| Molecular weight | 177.14 |
|---|---|
| Linear formula | NCCH2PO(OC2H5)2 |
| Assay | 98% |
| Boiling point | 101-102 °C/0.4 mmHg(lit.) |
| Density | 1.095 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.434(lit.) |
Hazard statements
- H315Causes skin irritation
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 1760 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 38 |
| Safety statements (S) | 26-28 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl cyanomethylphosphonate used for?
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Diethyl cyanomethylphosphonate is primarily used in organic synthesis, specifically for C-C bond formation and as a Horner-Wadsworth-Emmons reagent to synthesize alpha,beta-unsaturated nitriles.
What is the CAS number and chemical formula for Diethyl cyanomethylphosphonate?
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The CAS number is 2537-48-6 and the linear formula is NCCH2PO(OC2H5)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl cyanomethylphosphonate with an assay of 98%. This product is intended for research and laboratory use and is not represented as USP, EP, or BP grade.
How should Diethyl cyanomethylphosphonate be handled safely?
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Diethyl cyanomethylphosphonate is classified as an irritant (H315). Handle with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and use a suitable respirator.
Can Diethyl cyanomethylphosphonate be exported?
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Yes, Tech Serve Solutions specialises in supplying and exporting fine chemicals globally, including Diethyl cyanomethylphosphonate.
How can I request a sample or quote for Diethyl cyanomethylphosphonate?
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To request a sample or quote, please contact our sales team through the website or provide your details via the inquiry form.
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