Nipecotamide
Nipecotamide (CAS: 4138-26-5), with the molecular formula C6H12N2O and a molecular weight of 128.17 g/mol, is a versatile heterocyclic building block. This compound serves as a key intermediate in the synthesis of various complex molecules. Its primary utility lies in its application as a reactant for developing DPP-4 inhibitors, IKKβ inhibitors, and anti-HIV agents, among other pharmaceutical targets.
- IUPAC
- 3-Carbamoylpiperidine,3-Piperidinecarboxamide
- Synonyms
- 3-Carbamoylpiperidine3-Piperidinecarboxamide
DPP-4 Inhibitor Synthesis
Nipecotamide is utilised as a reactant in the synthetic pathways leading to Dipeptidyl Peptidase-4 (DPP-4) inhibitors, which are important in managing type 2 diabetes.
IKKβ Inhibitor Development
This compound acts as a building block for the creation of Inhibitor of Nuclear Factor Kappa-B Kinase subunit beta (IKKβ) inhibitors, relevant in inflammatory and autoimmune disease research.
Anti-HIV Agent Synthesis
Nipecotamide is employed as a precursor in the synthesis of novel agents designed to combat Human Immunodeficiency Virus (HIV).
Spiroimidazolidinone Synthesis
It serves as a reactant in the synthesis of spiroimidazolidinone NPC1L1 inhibitors, which are explored for their potential in managing cholesterol levels.
Sulfamide and Phosphodiesterase 5 Inhibitor Synthesis
The compound is a useful intermediate for producing sulfamides and phosphodiesterase 5 (PDE5) inhibitors, with applications in medicinal chemistry.
| Molecular weight | 128.17 |
|---|---|
| Empirical formula | C6H12N2O |
| Assay | 95% |
| Application | Reactant for synthesis of:• DPP-4 inhibitors1• IKKβ inhibitors2• Spiroimidazolidinone NPC1L1 inhibitors3• Sulfamides4• Phosphodiesterase 5 inhibtors5• Anti-HIV agents6 |
| Melting point | 103-106 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nipecotamide used for?
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Nipecotamide (CAS: 4138-26-5) is used as a reactant for the synthesis of various pharmaceutical intermediates and active compounds, including DPP-4 inhibitors, IKKβ inhibitors, spiroimidazolidinone NPC1L1 inhibitors, sulfamides, phosphodiesterase 5 inhibitors, and anti-HIV agents.
What is the CAS number and formula for Nipecotamide?
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The CAS number for Nipecotamide is 4138-26-5, and its empirical formula is C6H12N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nipecotamide with an assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Nipecotamide be handled safely?
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Nipecotamide is classified as a Warning with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). It should be handled with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, in a well-ventilated area.
Is Nipecotamide a controlled substance?
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Based on the provided data, Nipecotamide is not indicated as a controlled substance.
How is Nipecotamide packed and shipped?
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Nipecotamide is carefully packed to ensure safe transit and is available for export globally by Tech Serve Solutions.
How can I request a sample or quote for Nipecotamide?
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To request a sample or obtain a quote for Nipecotamide, please contact our sales team through the website or by phone.
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