Nicotinoyl chloride hydrochloride
Nicotinoyl chloride hydrochloride (CAS 20260-53-1, C6H4ClNO · HCl) is a pyridine derivative and a reactive acyl chloride. Its molecular weight is 178.02 g/mol. This compound serves as a key intermediate and building block in organic synthesis, particularly for the preparation of complex molecules within pharmaceutical research and chemical development. It is supplied by TSS with an assay of 97%.
Nucleoside and Nucleotide Analog Synthesis
Nicotinoyl chloride hydrochloride is employed in the synthesis of modified nucleosides, such as 1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil. This highlights its utility in creating building blocks for potential therapeutic agents.
Synthesis of Macrocyclic Compounds
The compound is used in the preparation of dinicotinoylated and diisonicotinoylated tetraaza[14]annulene derivatives. This application demonstrates its role in constructing complex macrocyclic structures.
Preparation of Novel Organic Materials
Nicotinoyl chloride hydrochloride has been utilised in the synthesis of bis(ethylenedithio)tetrathiafulvalene derivatives, indicating its application in the development of advanced organic materials with unique electronic properties.
| Molecular weight | 178.02 |
|---|---|
| Empirical formula | C6H4ClNO · HCl |
| Assay | 97% |
| Application | Nicotinoyl chloride hydrochloride was used in the preparation of :• 1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil1• 7,16-dinicotinoylated and/or 7,16-diisonicotinoylated compounds via reaction with tetraaza[14]annulene and its complexes2• bis(ethylenedithio)tetrathiafulvalene derivatives3 |
| Melting point | 151-157 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nicotinoyl chloride hydrochloride used for?
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Nicotinoyl chloride hydrochloride is used as a building block and intermediate in organic synthesis, particularly for preparing modified nucleosides, macrocyclic compounds, and novel organic materials.
What are the CAS number and formula for Nicotinoyl chloride hydrochloride?
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The CAS number for Nicotinoyl chloride hydrochloride is 20260-53-1, and its empirical formula (Hill notation) is C6H4ClNO · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nicotinoyl chloride hydrochloride with an assay of 97%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should Nicotinoyl chloride hydrochloride be handled safely?
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Nicotinoyl chloride hydrochloride causes severe skin burns and eye damage (H314). Handle with extreme caution, using appropriate personal protective equipment including eyeshields, face shields, gloves, and suitable respiratory protection.
How is Nicotinoyl chloride hydrochloride packed, shipped, and exported?
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Nicotinoyl chloride hydrochloride is packed and shipped according to UN 3261 (Class 8, Packing Group II) regulations for hazardous materials. TSS is experienced in global export.
How can I request a sample or quote for Nicotinoyl chloride hydrochloride?
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To request a sample or a quote, please contact our sales team through the website or by telephone, providing your specific requirements.
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