Nipecotic acid
Nipecotic acid (CAS 498-95-3, C6H11NO2) is a heterocyclic compound with a molecular weight of 129.16 g/mol. This bioactive small molecule serves as a key building block in chemical synthesis and is recognised for its role in neuroscience research. It functions as a GABA uptake inhibitor, making it valuable in studies related to neurotransmission and the development of therapeutic agents targeting the central nervous system.
- IUPAC
- (±)-β-Homoproline,3-Piperidinecarboxylic acid,3-Carboxypiperidine,Hexahydronicotinic acid
- Synonyms
- 3-Piperidinecarboxylic acid(±)-β-Homoproline3-CarboxypiperidineHexahydronicotinic acid
Neuroscience Research
Nipecotic acid is utilised in neuroscience to investigate the mechanisms of GABA uptake and neurotransmission. Its inhibitory effect on GABA transporters makes it a valuable tool for studying neuronal signalling pathways and developing potential treatments for neurological disorders.
Chemical Synthesis
As a heterocyclic building block, nipecotic acid is employed in the synthesis of more complex molecules. Its structure allows for diverse chemical modifications, facilitating the creation of novel compounds for pharmaceutical and chemical research applications.
Analytical Chemistry
Nipecotic acid has been used as a reference standard in analytical methods, such as capillary electrophoresis with laser-induced fluorescence detection, for the quantification of amino acid neurotransmitters in biological samples.
| Molecular weight | 129.16 |
|---|---|
| Empirical formula | C6H11NO2 |
| Assay | 98% |
| Solubility | water: soluble50 mg/mL, clear, colorless to faintly yellow |
| Application | Nipecotic acid was used in determination of the antiepileptic drug vigabatrin and the amino acid neurotransmitters in rat brain extracellular fluid by capillary electrophoresis with laser-induced fluorescence detection1. |
| Melting point | 261 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... SLC23A2(9962) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nipecotic acid used for?
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Nipecotic acid is primarily used in neuroscience research to study GABA uptake and neurotransmission, and as a building block in chemical synthesis. It has also been applied in analytical chemistry as a reference standard.
What is the CAS number and molecular formula for Nipecotic acid?
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The CAS number for Nipecotic acid is 498-95-3, and its molecular formula is C6H11NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nipecotic acid with an assay of 98%. This product is intended for research and laboratory use and is not supplied as USP, BP, or EP grade.
How should Nipecotic acid be handled safely?
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Nipecotic acid is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves, should be worn. Ensure adequate ventilation and avoid breathing dust.
Is Nipecotic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Nipecotic acid, and can arrange for its shipment worldwide.
How can I request a sample or quote for Nipecotic acid?
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To request a sample or a quote for Nipecotic acid, please contact our sales team through the website or by phone, providing your specific requirements.
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