Diethyl chlorophosphate
Diethyl chlorophosphate (CAS: 814-49-3) is a reactive organophosphorus compound with the linear formula (C2H5O)2P(O)Cl and a molecular weight of 172.55 g/mol. This chemical is primarily utilised as a versatile building block in organic synthesis and chemical manufacturing. Its phosphorus halide structure makes it valuable for introducing phosphoryl groups in various chemical reactions, facilitating the creation of complex molecules.
- IUPAC
- Diethyl phosphorochloridate
- Synonyms
- Diethyl phosphorochloridate

Organic Synthesis Reagent
Diethyl chlorophosphate serves as a key reagent in organic synthesis for the phosphorylation of alcohols, amines, and other nucleophiles. It is employed in the preparation of various organophosphorus compounds.
Chemical Intermediate
This compound functions as an intermediate in the synthesis of more complex chemical structures. Its reactivity allows for controlled reactions in the development of fine chemicals and specialty materials.
Phosphorus Compound Synthesis
It is used in the production of a range of phosphorus-containing compounds, which can find applications in diverse fields including agriculture and material science.
| Molecular weight | 172.55 |
|---|---|
| Linear formula | (C2H5O)2P(O)Cl |
| Assay | 97% |
| Boiling point | 60 °C/2 mmHg(lit.) |
| Density | 1.194 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.416(lit.) |
| Vapour pressure | 0.1 mmHg (25 °C) |
| Vapour density | 5.94 (vs air) |

Hazard statements
- H300Fatal if swallowed
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Transport (UN / ADR) | UN 3278 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl chlorophosphate used for?
+
Diethyl chlorophosphate is a valuable building block in organic synthesis and chemical manufacturing, primarily used for phosphorylating nucleophiles and as an intermediate in producing other organophosphorus compounds.
What is the CAS number and formula for Diethyl chlorophosphate?
+
The CAS number for Diethyl chlorophosphate is 814-49-3, and its linear formula is (C2H5O)2P(O)Cl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Diethyl chlorophosphate with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How is Diethyl chlorophosphate handled and shipped?
+
Diethyl chlorophosphate is classified under UN 3278, Hazard Class 6.1, Packing Group I. It is a highly toxic substance requiring stringent handling procedures, including appropriate personal protective equipment (Eyeshields, Faceshields, full-face respirator, Gloves, etc.) and respiratory protection. Shipping adheres to strict regulatory standards for hazardous materials.
How can I request a sample or quote for Diethyl chlorophosphate?
+
To request a sample or a quote for Diethyl chlorophosphate, please contact our sales team directly through the website or by phone.
What are the primary hazards associated with Diethyl chlorophosphate?
+
Diethyl chlorophosphate is highly toxic if swallowed, in contact with skin, or if inhaled (H300 + H310 + H330). It requires careful handling in a well-ventilated area with appropriate personal protective equipment to avoid exposure.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis