Diethyl (3-chloropropyl)malonate
Diethyl (3-chloropropyl)malonate (CAS 18719-43-2) is a halogenated malonate ester with the linear formula Cl(CH2)3CH(CO2C2H5)2. This organic building block possesses a molecular weight of 236.69 g/mol. It serves as a versatile intermediate in organic synthesis, particularly in the construction of carbon chains and heterocyclic compounds due to the reactivity of both the ester groups and the alkyl chloride moiety. Its application is primarily within chemical research and development.
Organic Synthesis Intermediate
Diethyl (3-chloropropyl)malonate is a valuable building block for introducing a functionalized three-carbon chain into organic molecules. It is frequently employed in alkylation reactions and cyclisation processes.
Heterocyclic Chemistry
The compound can be utilised in the synthesis of various heterocyclic systems. Reactions involving its malonate and halide functionalities allow for the formation of nitrogen, oxygen, or sulfur-containing rings.
Pharmaceutical Intermediate Precursor
As a functionalized malonate, it can serve as a precursor in the multi-step synthesis of complex pharmaceutical compounds and their intermediates, contributing to the development of new therapeutic agents.
| Molecular weight | 236.69 |
|---|---|
| Linear formula | Cl(CH2)3CH(CO2C2H5)2 |
| Assay | 97% |
| Boiling point | 136 °C/5 mmHg(lit.) |
| Density | 1.101 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.443(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl (3-chloropropyl)malonate used for?
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Diethyl (3-chloropropyl)malonate is primarily used as a versatile intermediate in organic synthesis for the construction of carbon chains and heterocyclic compounds, and as a precursor in the synthesis of complex pharmaceutical agents.
What are the CAS number and formula for Diethyl (3-chloropropyl)malonate?
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The CAS number for Diethyl (3-chloropropyl)malonate is 18719-43-2, and its linear formula is Cl(CH2)3CH(CO2C2H5)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl (3-chloropropyl)malonate with a minimum assay of 97%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Diethyl (3-chloropropyl)malonate be handled safely?
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Diethyl (3-chloropropyl)malonate is a warning substance classified with H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (e.g., type ABEK respirator filter or multi-purpose combination cartridge), should be used. Handle in a well-ventilated area.
How is Diethyl (3-chloropropyl)malonate packed and shipped?
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Diethyl (3-chloropropyl)malonate is carefully packed and exported by Tech Serve Solutions in compliance with all relevant shipping regulations to ensure safe transit globally.
How can I request a sample or quote for Diethyl (3-chloropropyl)malonate?
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To request a sample or a quote for Diethyl (3-chloropropyl)malonate, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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